How to predict higher-order variants?

luoyunan / ECNet

An evolutionary context-integrated deep learning framework for protein engineering

BSD 3-Clause "New" or "Revised" License

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How to predict higher-order variants? #3

Open eric-jm-lang opened 3 years ago

eric-jm-lang commented 3 years ago

Hello, In the ECNet paper, the possibility to generate higher-order mutant from training on low-order varaints data is demonstrated. However, the MTH3_HAEAESTABILIZED_Tawfik2015 example provided only predicts single point mutations. Could you please explain how to generate higher-order mutants predictions? Many thanks in advance

luoyunan commented 2 years ago

Sorry for the belated response. You can see an example of training on single mutants and predicting for double mutants at https://github.com/luoyunan/ECNet/issues/5#issuecomment-1059797060