:point_up::running: Modern Relay Starter Kit - Integrated with Relay, GraphQL, Express, ES6/ES7, JSX, Webpack, Babel, Material Design Lite, and PostCSS
You should not be using babel-node in production. It is unnecessarily heavy, with high memory usage due to the cache being stored in memory. You will also always experience a startup performance penalty as the entire app needs to be compiled on the fly.
Source: Babel CLI Documentation
Research that may help: https://medium.com/@Cuadraman/how-to-use-babel-for-production-5b95e7323c2f#.vg3mo8a5m
This is on my TODO list.