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malariagen / ag1000g-phase1-vgsc-report

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Discussion - open questions #138

Closed cclarkson closed 6 years ago

cclarkson commented 6 years ago

Paragraph listing open questions raised by study? Maybe include as part of wrap-up paragraph.

cclarkson commented 6 years ago

working on this now

cclarkson commented 6 years ago

Of all the items in the legacy discussion/open questions, there is only one that isn't either no longer relevant or included elsewhere:

As this is the most speculative, I am happy to leave this out of the discussion as I think it might break the nice flow we have there. @alimanfoo opinions?

NO LONGER RELEVANT/NOT INCLUDING

ALREADY COVERED

alimanfoo commented 6 years ago

SGTM

On Friday, January 19, 2018, Chris Clarkson notifications@github.com wrote:

Of all the items in the legacy discussion/open questions, there is only one that isn't either no longer relevant or included elsewhere:

  • Speculate on why \texttt{L995F} but not \texttt{L995S} has evolved secondary variation.

As this is the most speculative, I am happy to leave this out of the discussion as I think it might break the nice flow we have there. @alimanfoo https://github.com/alimanfoo opinions?

NO LONGER RELEVANT/NOT INCLUDING

  • Discuss weaknesses, caveats and potential improvements to method for estimating haplotype age.
  • Discuss accessibility, have we missed any functional variation?
  • HW disequilibrium in Gabon - what might be happening here?

ALREADY COVERED

  • What are the implications for insecticide resistance management? Realistically how could this information be used?
  • What about DDT? If prior selection for DDT resistance, how might this complicate the picture? Do we see any evidence for multiple phases of selection?

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cclarkson commented 6 years ago

Closing this issue then.