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manulera / discussions_curation

A repository for more broad discussion of curation
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Q: Annotating that localization of a protein depends on another one #14

Open manulera opened 2 years ago

manulera commented 2 years ago

Hi @ValWood I am annotating now klp2 cellular component to microtubule plus ends. Within GO, can we indicate that this localization depends on another protein (in this case mal3), or does this belong only to the phenotype ontologies?

manulera commented 2 years ago

Another question on this one. I want to indicate that in dli1D, dhc1 does not localize to the SPB during karyogamy.

Would this be considered a 'abolished protein localization during meiotic cell cycle'. In other words, are nuclear congression and karyogamy considered to be part of meoitic cell cycle? I suppose yes.

manulera commented 2 years ago

These are all related to #7

ValWood commented 2 years ago

Would this be considered a 'abolished protein localization during meiotic cell cycle'. In other words, are nuclear congression and karyogamy considered to be part of meoitic cell cycle? I suppose yes.

I have always assumed so, because it is after the "switch" from mitotic to meiotic growth.

ValWood commented 2 years ago

I am annotating now klp2 cellular component to microtubule plus ends. Within GO, can we indicate that this localization depends on another protein (in this case mal3), or does this belong only to the phenotype ontologies?

It depends ho much we know. If we know the function of Mal1 and how it acts on Klp2 we should be able to make this connection. If Mal1 acts as an adaptor we can do it in Canto. If it is indirect we might not be able to. Can discuss.

manulera commented 2 years ago

see #7 when curating this