I thought this might be of interest to you, to get native builds out.
As for the downstream dependencies: dnaio should be possible as well. Xopen is pure python, python-isal will not be able to build as ISA-L does not support it yet, and zlib-ng should handle it fine without issue. So that will require some twiddling in the xopen requirements (if I now the proper platform.architecture flag for macos arm64).
https://github.com/orgs/community/discussions/102846
Also supported by CIBuildWheel: https://cibuildwheel.pypa.io/en/stable/#usage
I thought this might be of interest to you, to get native builds out.
As for the downstream dependencies: dnaio should be possible as well. Xopen is pure python, python-isal will not be able to build as ISA-L does not support it yet, and zlib-ng should handle it fine without issue. So that will require some twiddling in the xopen requirements (if I now the proper platform.architecture flag for macos arm64).