markkukuismin / BONE

Genetic assignment of individuals to known source populations using network estimation tools.
GNU General Public License v3.0
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Can BONE handle admixture? #1

Open kwojtusik opened 2 years ago

kwojtusik commented 2 years ago

Hello Dr. @markkukuismin,

This is not an issue but a question about BONE.

As indicated by the title, I was curious if/how BONE might handle admixture. I am working on trying to conduct mixed stock analyses on an anadromous fish, however, some of our baseline populations show evidence of gene flow/admixture. However, our population genetic analyses showed that our baseline populations were in fact genetically distinct, despite this admixture.

We were going to use Rubias to conduct our mixture analyses, however the bayesian model it is built upon cannot handle any admixture among baseline populations, which led me to finding BONE.

So my question is, can BONE accurately assign mixture individuals in the face of admixture in the baseline populations?

Thank you.

-Kris

markkukuismin commented 2 years ago

Hello Kris,

the admixture in the baseline is not taken into account in the model part of the BONE procedure and very strong admixture in the baseline populations has an effect on the assignment accuracy. If you want to use BONE, I recommend that you use the WTA method which can somewhat mitigate the assignment error caused by the admixture in the baseline populations.

Best, Markku