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markowetzlab / CNsignatures

This is data and code from our first paper on copy number signatures (Macintyre et al., Nat Gen, 2018).
https://www.nature.com/articles/s41588-018-0179-8?proof=trueInJun
MIT License
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No convergence #4

Open vymao opened 3 years ago

vymao commented 3 years ago

Hi,

I am trying to fit the mixture models to generate my own signatures, but I keep getting what seems to be a convergence error: 

3 : *Error in FLXfit(model = model, concomitant = concomitant, control = control,  : 
    12 Log-likelihood: NaN

4 : *Error in FLXfit(model = model, concomitant = concomitant, control = control,  : 
    11 Log-likelihood: NaN

5 : *Error in FLXfit(model = model, concomitant = concomitant, control = control,  : 
    11 Log-likelihood: NaN

6 : *Error in FLXfit(model = model, concomitant = concomitant, control = control,  : 
    11 Log-likelihood: NaN

7 : *Error in FLXfit(model = model, concomitant = concomitant, control = control,  : 
    11 Log-likelihood: NaN

8 : *Error in FLXfit(model = model, concomitant = concomitant, control = control,  : 
    11 Log-likelihood: NaN

9 : *Error in FLXfit(model = model, concomitant = concomitant, control = control,  : 
    10 Log-likelihood: NaN

10 : *Error in FLXfit(model = model, concomitant = concomitant, control = control,  : 
    11 Log-likelihood: NaN

Error in (function (classes, fdef, mtable)  : 
  unable to find an inherited method for function 'getModel' for signature '"flexmix"'

Is there a way to remedy this before I have to change the script parameters myself?

Martingales commented 3 years ago

Hi Victor,

thanks for your interest in our work. Unfortunately I haven't encountered this error message and without some more detail I won't be able to help you. Depending on your background, it's probably easier for you to step through each function yourself to identify where exactly the error is produced.

Assuming, everything is going correct, what does your input data look like? How many samples do you have and how large are your feature distributions (the input to the mix models)? If they are small, maybe a higher K might not fit very and returns an error.

vymao commented 3 years ago

I looked at the traceback: 

5: stop(gettextf("unable to find an inherited method for function %s for signature %s", 
       sQuote(fdef@generic), sQuote(cnames)), domain = NA)
4: (function (classes, fdef, mtable) 
   {
       methods <- .findInheritedMethods(classes, fdef, mtable)
       if (length(methods) == 1L) 
           return(methods[[1L]])
       else if (length(methods) == 0L) {
           cnames <- paste0("\"", vapply(classes, as.character, 
               ""), "\"", collapse = ", ")
           stop(gettextf("unable to find an inherited method for function %s for signature %s", 
               sQuote(fdef@generic), sQuote(cnames)), domain = NA)
       }
       else stop("Internal error in finding inherited methods; didn't return a unique method", 
           domain = NA)
   })(list(structure("flexmix", package = "flexmix")), new("standardGeneric", 
       .Data = function (object, ...) 
       standardGeneric("getModel"), generic = structure("getModel", package = "modeltools"), 
       package = "modeltools", group = list(), valueClass = character(0), 
       signature = "object", default = NULL, skeleton = (function (object, 
           ...) 
       stop("invalid call in method dispatch to 'getModel' (no default method)", 
           domain = NA))(object, ...)), <environment>)
3: flexmix::getModel(fit, which = model_selection) at helper_functions.R#15
2: fitComponent(dat, seed = seed, model_selection = model_selection, 
       min_prior = min_prior, niter = niter, nrep = nrep, min_comp = min_comp, 
       max_comp = max_comp) at main_functions.R#184
1: fitMixtureModels(CN_features)

and it seems to be an error trying to generate bpchrarm_mm. I looked at the input features to fitting this: 

CN_features[["bpchrarm"]][,2]
   [1] "13"   "24"   "33"   "18"   "31"   "40"   "42"   "7"    "6"    "18"  
  [11] "38"   "22"   "29"   "3"    "58"   "13"   "1"    "13"   "16"   "10"  
  [21] "16"   "9"    "20"   "9"    "13"   "0"    "19"   "0"    "9"    "1"   
  [31] "10"   "12"   "13"   "8"    "10"   "1"    "21"   "35"   "26"   "8"   
  [41] "15"   "0"    "7"    "1"    "25"   "23"   "3"    "1"    "0"    "1"   
  [51] "0"    "1"    "0"    "1"    "0"    "1"    "0"    "2"    "4"    "1"   
  [61] "0"    "2"    "2"    "2"    "0"    "1"    "0"    "2"    "1"    "1"   
  [71] "1"    "0"    "0"    "0"    "2"    "1"    "1"    "1"    "1"    "1"   
  [81] "1"    "1"    "0"    "2"    "0"    "1"    "1"    "0"    "1"    "1"   
  [91] "0"    "1"    "3"    "3"    "2"    "1"    "5"    "5"    "2"    "3"   
 [101] "2"    "2"    "0"    "8"    "6"    "2"    "2"    "7"    "2"    "3"   
 [111] "8"    "2"    "9"    "6"    "3"    "1"    "6"    "0"    "4"    "0"   
 [121] "7"    "1"    "4"    "5"    "1"    "2"    "2"    "1"    "0"    "2"   
 [131] "2"    "2"    "3"    "0"    "1"    "1"    "4"    "5"    "0"    "0"   
 [141] "2"    "2"    "0"    "2"    "0"    "1"    "9"    "1"    "0"    "2"   
 [151] "0"    "2"    "0"    "1"    "0"    "2"    "1"    "3"    "0"    "1"   
 [161] "3"    "2"    "1"    "1"    "1"    "0"    "5"    "0"    "1"    "1"   
 [171] "1"    "2"    "1"    "1"    "1"    "2"    "0"    "2"    "0"    "1"   
 [181] "1"    "0"    "1"    "1"    "0"    "1"    "70"   "58"   "5"    "12"  
 [191] "0"    "1"    "0"    "1"    "0"    "1"    "2"    "3"    "2"    "3"   
 [201] "0"    "2"    "31"   "31"   "2"    "1"    "39"   "32"   "1"    "2"   
 [211] "1"    "0"    "0"    "0"    "3"    "1"    "2"    "6"    "1"    "1"   
 [221] "3"    "2"    "0"    "4"    "0"    "1"    "1"    "0"    "3"    "1"   
 [231] "0"    "3"    "1"    "1"    "1"    "1"    "0"    "31"   "0"    "1"   
 [241] "0"    "1"    "0"    "2"    "0"    "1"    "0"    "3"    "3"    "1"   
 [251] "0"    "1"    "0"    "2"    "2"    "2"    "1"    "0"    "0"    "0"   
 [261] "1"    "1"    "1"    "1"    "1"    "1"    "1"    "1"    "0"    "2"   
 [271] "0"    "1"    "1"    "0"    "1"    "1"    "0"    "3"    "1"    "5"   
 [281] "11"   "2"    "2"    "5"    "0"    "1"    "2"    "1"    "1"    "2"   
 [291] "0"    "3"    "3"    "2"    "1"    "1"    "0"    "1"    "0"    "2"   
 [301] "3"    "1"    "30"   "0"    "2"    "0"    "1"    "0"    "2"    "1"   
 [311] "1"    "1"    "1"    "1"    "0"    "6"    "0"    "1"    "7"    "0"   
 [321] "1"    "0"    "1"    "1"    "1"    "5"    "0"    "1"    "0"    "1"   
 [331] "0"    "1"    "0"    "2"    "0"    "1"    "0"    "1"    "0"    "2"   
 [341] "1"    "2"    "6"    "1"    "0"    "2"    "1"    "1"    "1"    "0"   
 [351] "1"    "0"    "1"    "1"    "1"    "1"    "1"    "1"    "1"    "2"   
 [361] "0"    "2"    "0"    "1"    "2"    "0"    "1"    "1"    "0"    "1"   
 [371] "2"    "1"    "32"   "5"    "4"    "3"    "23"   "19"   "20"   "2"   
 [381] "4"    "2"    "30"   "2"    "14"   "4"    "1"    "4"    "0"    "1"   
 [391] "2"    "2"    "1"    "6"    "7"    "0"    "6"    "0"    "5"    "1"   
 [401] "1"    "1"    "1"    "1"    "1"    "1"    "0"    "2"    "0"    "1"   
 [411] "1"    "0"    "1"    "1"    "2"    "1"    "0"    "0"    "13"   "6"   
 [421] "5"    "6"    "1"    "9"    "4"    "1"    "7"    "3"    "2"    "3"   
 [431] "4"    "3"    "7"    "2"    "16"   "11"   "5"    "1"    "1"    "12"  
 [441] "7"    "1"    "10"   "0"    "6"    "0"    "3"    "1"    "2"    "2"   
 [451] "4"    "9"    "2"    "2"    "23"   "1"    "0"    "5"    "3"    "1"   
 [461] "13"   "1"    "0"    "3"    "3"    "0"    "1"    "1"    "7"    "1"   
 [471] "0"    "1"    "4"    "1"    "0"    "1"    "0"    "1"    "4"    "1"   
 [481] "0"    "2"    "1"    "1"    "1"    "1"    "0"    "2"    "1"    "1"   
 [491] "1"    "0"    "2"    "0"    "1"    "0"    "2"    "1"    "1"    "1"   
 [501] "1"    "2"    "0"    "2"    "0"    "1"    "1"    "0"    "1"    "1"   
 [511] "0"    "1"    "4"    "1"    "0"    "3"    "0"    "1"    "0"    "1"   
 [521] "0"    "1"    "0"    "5"    "0"    "1"    "1"    "2"    "0"    "2"   
 [531] "0"    "1"    "0"    "2"    "1"    "4"    "1"    "0"    "1"    "0"   
 [541] "1"    "1"    "1"    "2"    "1"    "2"    "1"    "1"    "0"    "2"   
 [551] "0"    "1"    "1"    "0"    "1"    "1"    "0"    "1"    "0"    "0"   
 [561] "1"    "4"    "0"    "1"    "0"    "12"   "2"    "1"    "8"    "1"   
 [571] "0"    "5"    "0"    "1"    "6"    "3"    "3"    "3"    "0"    "3"   
 [581] "0"    "1"    "3"    "1"    "1"    "0"    "9"    "0"    "3"    "0"   
 [591] "3"    "2"    "1"    "2"    "5"    "2"    "2"    "4"    "0"    "1"   
 [601] "1"    "0"    "1"    "0"    "0"    "1"    "0"    "0"    "20"   "12"  
 [611] "15"   "2"    "8"    "9"    "14"   "9"    "8"    "11"   "11"   "5"   
 [621] "7"    "3"    "14"   "2"    "6"    "31"   "13"   "1"    "3"    "2"   
 [631] "1"    "5"    "11"   "0"    "7"    "0"    "7"    "1"    "2"    "4"   
 [641] "4"    "1"    "3"    "2"    "4"    "3"    "0"    "1"    "5"    "0"   
 [651] "3"    "1"    "4"    "2"    "0"    "0"    "5"    "6"    "2"    "5"   
 [661] "0"    "5"    "2"    "1"    "10"   "2"    "3"    "6"    "2"    "3"   
 [671] "4"    "2"    "0"    "4"    "17"   "29"   "5"    "2"    "4"    "2"   
 [681] "1"    "0"    "2"    "0"    "1"    "1"    "4"    "3"    "2"    "4"   
 [691] "3"    "1"    "0"    "2"    "0"    "1"    "3"    "0"    "1"    "1"   
 [701] "8"    "1"    "85"   "48"   "21"   "34"   "41"   "30"   "72"   "40"  
 [711] "75"   "35"   "195"  "22"   "79"   "7"    "79"   "7"    "8"    "41"  
 [721] "28"   "13"   "65"   "26"   "80"   "11"   "43"   "0"    "31"   "0"   
 [731] "16"   "1"    "66"   "19"   "87"   "6"    "16"   "11"   "26"   "19"  
 [741] "4"    "5"    "3"    "0"    "20"   "1"    "20"   "9"    "33"   "16"  
 [751] "33"   "29"   "58"   "21"   "28"   "15"   "21"   "6"    "86"   "24"  
 [761] "32"   "7"    "36"   "6"    "20"   "43"   "8"    "3"    "20"   "41"  
 [771] "44"   "11"   "33"   "0"    "136"  "0"    "21"   "1"    "23"   "26"  
 [781] "88"   "53"   "5"    "2"    "5"    "30"   "1"    "6"    "5"    "2"   
 [791] "3"    "1"    "89"   "13"   "1"    "1"    "0"    "3"    "0"    "1"   
 [801] "0"    "1"    "0"    "1"    "2"    "2"    "1"    "3"    "1"    "2"   
 [811] "3"    "3"    "3"    "4"    "0"    "2"    "3"    "1"    "1"    "0"   
 [821] "0"    "0"    "1"    "1"    "4"    "3"    "1"    "1"    "1"    "1"   
 [831] "0"    "2"    "0"    "1"    "1"    "0"    "1"    "1"    "0"    "1"   
 [841] "0"    "0"    "11"   "43"   "2"    "1"    "2"    "3"    "1"    "2"   
 [851] "8"    "32"   "4"    "2"    "1"    "1"    "2"    "2"    "0"    "7"   
 [861] "0"    "1"    "0"    "4"    "3"    "1"    "3"    "0"    "4"    "0"   
 [871] "4"    "1"    "1"    "6"    "3"    "1"    "43"   "10"   "0"    "4"   
 [881] "0"    "3"    "3"    "0"    "1"    "1"    "2"    "4"    "0"    "0"   
 [891] "20"   "2"    "11"   "24"   "7"    "1"    "10"   "2"    "2"    "2"   
 [901] "22"   "4"    "9"    "3"    "0"    "15"   "8"    "2"    "28"   "3"   
 [911] "2"    "6"    "4"    "1"    "48"   "0"    "13"   "0"    "6"    "1"   
 [921] "2"    "5"    "13"   "1"    "0"    "2"    "4"    "7"    "0"    "1"   
 [931] "34"   "0"    "0"    "1"    "0"    "2"    "0"    "0"    "27"   "28"  
 [941] "71"   "17"   "18"   "19"   "126"  "5"    "61"   "24"   "16"   "18"  
 [951] "42"   "25"   "35"   "7"    "7"    "31"   "15"   "1"    "16"   "17"  
 [961] "15"   "1"    "11"   "0"    "2"    "0"    "24"   "1"    "25"   "6"   
 [971] "24"   "3"    "46"   "4"    "6"    "9"    "0"    "1"    "4"    "0"   
 [981] "1"    "1"    "5"    "3"    "3"    "3"    "0"    "1"    "3"    "1"   
 [991] "2"    "1"    "3"    "1"    "0"    "2"    "0"    "2"    "4"    "3"   
[1001] "2"    "2"    "6"    "1"    "4"    "3"    "1"    "2"    "1"    "0"   
[1011] "0"    "0"    "1"    "1"    "2"    "1"    "1"    "2"    "1"    "2"   
[1021] "2"    "2"    "0"    "1"    "1"    "0"    "1"    "1"    "0"    "1"   
[1031] "0"    "0"    "6"    "13"   "12"   "16"   "5"    "10"   "11"   "11"  
[1041] "27"   "4"    "12"   "9"    "21"   "4"    "15"   "40"   "0"    "6"   
[1051] "1"    "1"    "1"    "4"    "5"    "1"    "2"    "0"    "6"    "0"   
[1061] "3"    "1"    "3"    "2"    "5"    "14"   "2"    "2"    "1"    "2"   
[1071] "0"    "1"    "1"    "0"    "3"    "1"    "2"    "2"    "1"    "1"   
[1081] "26"   "31"   "20"   "11"   "30"   "22"   "16"   "7"    "21"   "15"  
[1091] "25"   "14"   "12"   "8"    "16"   "16"   "13"   "31"   "2"    "3"   
[1101] "5"    "8"    "30"   "12"   "31"   "0"    "10"   "0"    "5"    "1"   
[1111] "3"    "6"    "4"    "11"   "15"   "5"    "14"   "26"   "5"    "4"   
[1121] "9"    "0"    "10"   "1"    "6"    "10"   "1"    "1"    "0"    "1"   
[1131] "0"    "1"    "0"    "1"    "0"    "1"    "0"    "2"    "2"    "1"   
[1141] "0"    "2"    "1"    "2"    "0"    "2"    "0"    "2"    "1"    "2"   
[1151] "1"    "0"    "1"    "0"    "1"    "1"    "1"    "1"    "1"    "1"   
[1161] "1"    "1"    "0"    "2"    "0"    "1"    "1"    "0"    "1"    "1"   
[1171] "0"    "1"    "9"    "20"   "9"    "5"    "6"    "1"    "3"    "3"   
[1181] "12"   "12"   "0"    "14"   "2"    "35"   "101"  "18"   "2"    "7"   
[1191] "19"   "1"    "22"   "4"    "5"    "12"   "9"    "0"    "7"    "0"   
[1201] "7"    "0"    "24"   "2"    "66"   "23"   "3"    "1"    "0"    "3"   
[1211] "0"    "2"    "3"    "0"    "52"   "0"    "2"    "11"   "13"   "11"  
[1221] "10"   "6"    "11"   "20"   "10"   "7"    "18"   "2"    "10"   "6"   
[1231] "79"   "45"   "2"    "12"   "5"    "15"   "9"    "3"    "3"    "4"   
[1241] "6"    "5"    "5"    "0"    "22"   "0"    "5"    "1"    "11"   "3"   
[1251] "5"    "2"    "8"    "2"    "1"    "2"    "2"    "13"   "5"    "0"   
[1261] "13"   "1"    "5"    "3"    "0"    "0"    "1"    "1"    "2"    "1"   
[1271] "0"    "1"    "0"    "1"    "0"    "2"    "2"    "2"    "2"    "1"   
[1281] "0"    "2"    "1"    "2"    "0"    "1"    "0"    "2"    "1"    "1"   
[1291] "1"    "0"    "0"    "0"    "1"    "1"    "1"    "1"    "1"    "1"   
[1301] "1"    "1"    "0"    "2"    "0"    "1"    "1"    "0"    "1"    "1"   
[1311] "0"    "1"    "0"    "0"    "1"    "2"    "0"    "4"    "2"    "1"   
[1321] "0"    "1"    "0"    "3"    "0"    "7"    "0"    "1"    "0"    "2"   
[1331] "1"    "2"    "1"    "1"    "2"    "2"    "1"    "1"    "1"    "0"   
[1341] "2"    "0"    "1"    "1"    "2"    "1"    "3"    "1"    "5"    "3"   
[1351] "0"    "2"    "2"    "1"    "1"    "0"    "4"    "1"    "0"    "3"   
[1361] "1"    "1"    "0"    "1"    "0"    "1"    "0"    "2"    "0"    "1"   
[1371] "0"    "2"    "2"    "1"    "0"    "2"    "2"    "2"    "0"    "2"   
[1381] "0"    "2"    "1"    "1"    "1"    "0"    "0"    "0"    "1"    "1"   
[1391] "1"    "1"    "1"    "1"    "1"    "2"    "0"    "1"    "0"    "1"   
[1401] "1"    "0"    "1"    "1"    "0"    "1"    "5"    "6"    "0"    "1"   
[1411] "30"   "1"    "0"    "4"    "0"    "1"    "4"    "5"    "0"    "1"   
[1421] "0"    "2"    "1"    "2"    "11"   "1"    "1"    "4"    "5"    "3"   
[1431] "5"    "0"    "3"    "0"    "1"    "1"    "6"    "4"    "1"    "1"   
[1441] "4"    "1"    "0"    "2"    "0"    "1"    "1"    "0"    "1"    "1"   
[1451] "0"    "1"    "0"    "0"    "3"    "3"    "1"    "2"    "0"    "1"   
[1461] "0"    "2"    "0"    "4"    "29"   "10"   "7"    "8"    "10"   "4"   
[1471] "24"   "2"    "0"    "1"    "0"    "2"    "24"   "5"    "2"    "0"   
[1481] "1"    "0"    "1"    "1"    "1"    "1"    "5"    "1"    "2"    "2"   
[1491] "16"   "7"    "1"    "1"    "1"    "0"    "1"    "1"    "0"    "2"   
[1501] "14"   "10"   "4"    "2"    "2"    "10"   "4"    "1"    "0"    "2"   
[1511] "0"    "9"    "2"    "3"    "2"    "14"   "5"    "3"    "3"    "1"   
[1521] "2"    "2"    "1"    "2"    "6"    "0"    "26"   "0"    "7"    "0"   
[1531] "1"    "9"    "3"    "6"    "27"   "1"    "2"    "2"    "0"    "1"   
[1541] "1"    "0"    "4"    "1"    "0"    "3"    "4"    "7"    "20"   "3"   
[1551] "10"   "9"    "18"   "7"    "21"   "5"    "8"    "4"    "4"    "4"   
[1561] "47"   "11"   "1"    "4"    "15"   "2"    "3"    "7"    "18"   "1"   
[1571] "8"    "0"    "12"   "0"    "7"    "1"    "17"   "30"   "10"   "1"   
[1581] "5"    "6"    "1"    "17"   "0"    "5"    "1"    "0"    "1"    "1"   
[1591] "0"    "5"    "1"    "1"    "0"    "1"    "0"    "1"    "2"    "1"   
[1601] "0"    "1"    "0"    "2"    "0"    "1"    "0"    "1"    "1"    "1"   
[1611] "0"    "1"    "0"    "1"    "1"    "1"    "1"    "0"    "0"    "0"   
[1621] "1"    "1"    "2"    "2"    "1"    "4"    "1"    "1"    "0"    "2"   
[1631] "0"    "1"    "1"    "0"    "2"    "1"    "0"    "1"    "0"    "0"   
[1641] "25"   "5"    "0"    "1"    "0"    "1"    "17"   "2"    "0"    "1"   
[1651] "0"    "2"    "3"    "24"   "0"    "3"    "1"    "3"    "0"    "2"   
[1661] "0"    "2"    "104"  "1"    "3"    "0"    "0"    "0"    "1"    "1"   
[1671] "2"    "2"    "1"    "1"    "1"    "2"    "0"    "2"    "0"    "1"   
[1681] "1"    "0"    "1"    "1"    "2"    "1"    "3"    "1"    "2"    "1"   
[1691] "0"    "1"    "0"    "2"    "0"    "1"    "1"    "1"    "2"    "1"   
[1701] "2"    "2"    "0"    "2"    "1"    "1"    "0"    "2"    "1"    "1"   
[1711] "1"    "0"    "1"    "0"    "1"    "1"    "1"    "3"    "1"    "1"   
[1721] "1"    "1"    "0"    "2"    "0"    "1"    "1"    "0"    "1"    "1"   
[1731] "0"    "1"    "8"    "4"    "2"    "6"    "4"    "5"    "4"    "3"   
[1741] "11"   "4"    "7"    "4"    "2"    "1"    "0"    "2"    "2"    "3"   
[1751] "0"    "1"    "0"    "3"    "4"    "1"    "1"    "0"    "1"    "0"   
[1761] "1"    "1"    "2"    "1"    "1"    "3"    "3"    "1"    "0"    "2"   
[1771] "0"    "1"    "1"    "0"    "1"    "1"    "2"    "1"    "5"    "2"   
[1781] "2"    "7"    "0"    "1"    "0"    "1"    "0"    "1"    "0"    "4"   
[1791] "0"    "1"    "0"    "2"    "3"    "2"    "0"    "1"    "0"    "2"   
[1801] "1"    "1"    "3"    "0"    "17"   "0"    "1"    "0"    "4"    "1"   
[1811] "1"    "1"    "2"    "1"    "0"    "2"    "0"    "1"    "1"    "0"   
[1821] "5"    "0"    "0"    "1"    "8"    "1"    "0"    "109"  "1"    "1"   
[1831] "2"    "2"    "4"    "2"    "0"    "3"    "0"    "1"    "2"    "8"   
[1841] "3"    "3"    "2"    "1"    "0"    "4"    "7"    "3"    "1"    "0"   
[1851] "0"    "0"    "1"    "1"    "1"    "1"    "20"   "2"    "1"    "2"   
[1861] "2"    "3"    "0"    "1"    "2"    "0"    "3"    "1"    "0"    "1"   
[1871] "26"   "26"   "12"   "19"   "15"   "12"   "24"   "5"    "13"   "4"   
[1881] "12"   "19"   "11"   "7"    "14"   "20"   "7"    "13"   "14"   "1"   
[1891] "12"   "108"  "10"   "11"   "3"    "0"    "4"    "0"    "13"   "1"   
[1901] "3"    "11"   "20"   "1"    "8"    "3"    "38"   "4"    "8"    "10"  
[1911] "4"    "0"    "5"    "1"    "15"   "5"    "6"    "1"    "4"    "3"   
[1921] "4"    "41"   "2"    "1"    "7"    "1"    "5"    "3"    "0"    "1"   
[1931] "5"    "1"    "1"    "26"   "6"    "3"    "2"    "2"    "3"    "1"   
[1941] "1"    "0"    "9"    "0"    "3"    "1"    "2"    "3"    "4"    "1"   
[1951] "1"    "1"    "0"    "2"    "2"    "5"    "1"    "0"    "1"    "1"   
[1961] "0"    "1"    "0"    "0"    "15"   "9"    "60"   "11"   "62"   "10"  
[1971] "7"    "1"    "12"   "5"    "18"   "9"    "8"    "13"   "6"    "2"   
[1981] "7"    "6"    "51"   "6"    "3"    "6"    "8"    "18"   "3"    "0"   
[1991] "14"   "0"    "13"   "1"    "27"   "8"    "4"    "4"    "4"    "6"   
[2001] "12"   "6"    "12"   "4"    "4"    "0"    "2"    "1"    "7"    "20"  
[2011] "11"   "15"   "14"   "6"    "6"    "11"   "15"   "17"   "32"   "21"  
[2021] "10"   "10"   "19"   "9"    "18"   "3"    "8"    "13"   "13"   "3"   
[2031] "11"   "20"   "19"   "7"    "22"   "0"    "6"    "0"    "6"    "1"   
[2041] "5"    "6"    "5"    "5"    "16"   "1"    "1"    "4"    "8"    "8"   
[2051] "7"    "0"    "6"    "1"    "4"    "5"    "34"   "2"    "1"    "4"   
[2061] "3"    "3"    "8"    "6"    "6"    "1"    "21"   "4"    "5"    "1"   
[2071] "2"    "2"    "8"    "5"    "5"    "3"    "2"    "5"    "9"    "1"   
[2081] "5"    "0"    "1"    "0"    "1"    "1"    "4"    "5"    "3"    "1"   
[2091] "1"    "1"    "2"    "4"    "0"    "1"    "5"    "0"    "1"    "1"   
[2101] "4"    "2"    "1"    "1"    "0"    "5"    "0"    "4"    "0"    "1"   
[2111] "0"    "1"    "0"    "2"    "0"    "1"    "13"   "3"    "2"    "3"   
[2121] "0"    "1"    "4"    "3"    "170"  "3"    "1"    "0"    "0"    "0"   
[2131] "35"   "1"    "1"    "3"    "1"    "2"    "1"    "1"    "1"    "5"   
[2141] "1"    "1"    "1"    "0"    "1"    "1"    "25"   "4"    "90"   "105" 
[2151] "108"  "63"   "125"  "44"   "68"   "38"   "94"   "31"   "103"  "80"  
[2161] "74"   "48"   "74"   "20"   "67"   "42"   "74"   "33"   "143"  "297" 
[2171] "47"   "30"   "42"   "0"    "85"   "0"    "65"   "0"    "26"   "44"  
[2181] "40"   "16"   "37"   "20"   "27"   "13"   "23"   "23"   "55"   "0"   
[2191] "29"   "0"    "38"   "51"   "29"   "12"   "70"   "218"  "0"    "5"   
[2201] "25"   "10"   "10"   "1"    "11"   "12"   "4"    "1"    "2"    "6"   
[2211] "1"    "10"   "7"    "1"    "16"   "2"    "6"    "2"    "5"    "0"   
[2221] "5"    "0"    "4"    "1"    "1"    "1"    "10"   "6"    "1"    "1"   
[2231] "0"    "3"    "3"    "2"    "1"    "0"    "5"    "1"    "29"   "3"   
[2241] "15"   "11"   "33"   "5"    "12"   "11"   "1"    "4"    "3"    "3"   
[2251] "2"    "7"    "14"   "12"   "2"    "6"    "1"    "5"    "4"    "7"   
[2261] "41"   "6"    "7"    "15"   "1"    "0"    "2"    "0"    "4"    "1"   
[2271] "2"    "4"    "3"    "1"    "3"    "24"   "2"    "20"   "0"    "3"   
[2281] "4"    "0"    "1"    "1"    "9"    "14"   "32"   "3"    "5"    "1"   
[2291] "2"    "15"   "11"   "5"    "10"   "7"    "11"   "8"    "5"    "3"   
[2301] "2"    "1"    "4"    "2"    "2"    "7"    "4"    "3"    "3"    "21"  
[2311] "5"    "0"    "1"    "0"    "5"    "1"    "3"    "7"    "8"    "1"   
[2321] "2"    "3"    "0"    "6"    "0"    "3"    "1"    "0"    "8"    "1"   
[2331] "4"    "1"    "1"    "1"    "0"    "3"    "0"    "1"    "0"    "1"   
[2341] "0"    "1"    "0"    "2"    "1"    "1"    "1"    "2"    "0"    "2"   
[2351] "0"    "1"    "1"    "2"    "1"    "1"    "3"    "0"    "6"    "0"   
[2361] "1"    "1"    "1"    "2"    "1"    "1"    "1"    "1"    "0"    "2"   
[2371] "0"    "1"    "1"    "0"    "4"    "1"    "0"    "1"    "0"    "0"   
[2381] "2"    "6"    "2"    "2"    "0"    "2"    "0"    "2"    "1"    "1"   
[2391] "2"    "4"    "2"    "3"    "0"    "3"    "2"    "2"    "0"    "1"   
[2401] "0"    "3"    "1"    "2"    "2"    "0"    "2"    "0"    "1"    "1"   
[2411] "3"    "1"    "3"    "2"    "1"    "1"    "1"    "1"    "0"    "1"   
[2421] "1"    "0"    "1"    "1"    "1"    "4"    "0"    "0"    "15"   "3"   
[2431] "4"    "4"    "7"    "1"    "32"   "1"    "21"   "5"    "4"    "8"   
[2441] "4"    "8"    "5"    "3"    "1"    "4"    "17"   "37"   "2"    "2"   
[2451] "2"    "4"    "5"    "0"    "1"    "0"    "4"    "1"    "1"    "1"   
[2461] "3"    "1"    "7"    "2"    "0"    "2"    "2"    "1"    "1"    "0"   
[2471] "9"    "1"    "5"    "1"    "0"    "0"    "3"    "1"    "0"    "1"   
[2481] "0"    "2"    "0"    "1"    "0"    "1"    "0"    "2"    "1"    "2"   
[2491] "0"    "2"    "1"    "2"    "0"    "1"    "0"    "1"    "1"    "3"   
[2501] "1"    "0"    "1"    "0"    "1"    "1"    "2"    "2"    "1"    "1"   
[2511] "1"    "1"    "0"    "1"    "0"    "1"    "1"    "0"    "1"    "1"   
[2521] "0"    "1"    "5"    "6"    "0"    "5"    "2"    "3"    "2"    "2"   
[2531] "3"    "1"    "28"   "22"   "2"    "1"    "0"    "2"    "1"    "3"   
[2541] "1"    "1"    "9"    "13"   "1"    "1"    "1"    "0"    "1"    "0"   
[2551] "6"    "1"    "4"    "1"    "2"    "4"    "25"   "2"    "0"    "1"   
[2561] "0"    "1"    "1"    "0"    "1"    "1"    "0"    "2"    "1"    "0"   
[2571] "4"    "6"    "0"    "1"    "1"    "1"    "0"    "1"    "0"    "1"   
[2581] "0"    "2"    "2"    "1"    "0"    "4"    "3"    "7"    "2"    "1"   
[2591] "0"    "2"    "1"    "1"    "1"    "0"    "0"    "0"    "1"    "1"   
[2601] "1"    "1"    "1"    "1"    "1"    "2"    "0"    "2"    "0"    "1"   
[2611] "1"    "0"    "1"    "1"    "0"    "1"    "4"    "2"    "5"    "1"   
[2621] "36"   "12"   "2"    "1"    "21"   "1"    "10"   "10"   "0"    "9"   
[2631] "2"    "2"    "0"    "8"    "12"   "1"    "3"    "1"    "6"    "44"  
[2641] "13"   "0"    "0"    "0"    "0"    "1"    "4"    "1"    "0"    "3"   
[2651] "19"   "2"    "0"    "2"    "0"    "3"    "19"   "0"    "0"    "1"   
[2661] "2"    "28"   "15"   "13"   "5"    "4"    "21"   "6"    "13"   "19"  
[2671] "10"   "83"   "2"    "5"    "1"    "9"    "17"   "18"   "9"    "6"   
[2681] "6"    "6"    "13"   "1"    "21"   "2"    "3"    "0"    "15"   "0"   
[2691] "3"    "1"    "4"    "3"    "7"    "1"    "4"    "4"    "94"   "6"   
[2701] "9"    "3"    "3"    "0"    "4"    "1"    "6"    "3"    "3"    "2"   
[2711] "2"    "3"    "1"    "3"    "4"    "3"    "5"    "2"    "1"    "2"   
[2721] "0"    "2"    "0"    "6"    "9"    "3"    "6"    "43"   "3"    "1"   
[2731] "9"    "5"    "5"    "0"    "8"    "0"    "3"    "1"    "2"    "3"   
[2741] "3"    "5"    "1"    "3"    "0"    "2"    "2"    "1"    "2"    "0"   
[2751] "4"    "1"    "3"    "2"    "1"    "9"    "0"    "3"    "0"    "2"   
[2761] "2"    "1"    "0"    "1"    "0"    "2"    "0"    "1"    "4"    "2"   
[2771] "1"    "5"    "5"    "1"    "2"    "2"    "1"    "1"    "2"    "0"   
[2781] "1"    "0"    "3"    "1"    "1"    "1"    "1"    "1"    "1"    "1"   
[2791] "0"    "2"    "0"    "2"    "1"    "0"    "4"    "1"    "0"    "1"   
[2801] "0"    "0"    "1"    "1"    "3"    "5"    "5"    "15"   "0"    "1"   
[2811] "0"    "1"    "2"    "3"    "0"    "1"    "2"    "3"    "0"    "6"   
[2821] "0"    "3"    "2"    "2"    "1"    "5"    "3"    "0"    "6"    "0"   
[2831] "1"    "1"    "1"    "1"    "3"    "1"    "1"    "1"    "1"    "1"   
[2841] "4"    "1"    "1"    "0"    "5"    "1"    "1"    "1"    "0"    "0"   
[2851] "1"    "2"    "0"    "1"    "0"    "1"    "0"    "3"    "0"    "4"   
[2861] "0"    "2"    "0"    "1"    "0"    "2"    "1"    "3"    "4"    "1"   
[2871] "0"    "1"    "1"    "1"    "3"    "0"    "1"    "0"    "1"    "1"   
[2881] "2"    "1"    "1"    "1"    "1"    "2"    "0"    "2"    "0"    "1"   
[2891] "1"    "0"    "1"    "1"    "0"    "1"    "2"    "15"   "4"    "1"   
[2901] "2"    "18"   "8"    "9"    "5"    "1"    "2"    "3"    "0"    "1"   
[2911] "11"   "5"    "6"    "3"    "14"   "4"    "1"    "1"    "1"    "1"   
[2921] "2"    "0"    "8"    "0"    "2"    "1"    "6"    "5"    "2"    "1"   
[2931] "2"    "3"    "3"    "2"    "0"    "1"    "5"    "0"    "1"    "1"   
[2941] "7"    "3"    "1"    "2"    "0"    "1"    "0"    "1"    "0"    "1"   
[2951] "2"    "1"    "0"    "4"    "0"    "1"    "0"    "2"    "0"    "2"   
[2961] "0"    "1"    "0"    "2"    "1"    "1"    "1"    "0"    "0"    "0"   
[2971] "1"    "1"    "1"    "2"    "1"    "1"    "1"    "1"    "0"    "2"   
[2981] "1"    "1"    "1"    "0"    "1"    "1"    "0"    "1"    "1"    "3"   
[2991] "0"    "2"    "0"    "2"    "0"    "1"    "0"    "1"    "0"    "2"   
[3001] "1"    "1"    "1"    "1"    "0"    "5"    "1"    "1"    "0"    "2"   
[3011] "1"    "1"    "1"    "0"    "4"    "0"    "1"    "1"    "3"    "2"   
[3021] "1"    "2"    "1"    "2"    "0"    "1"    "0"    "1"    "1"    "0"   
[3031] "2"    "1"    "0"    "1"    "0"    "0"    "2"    "4"    "0"    "1"   
[3041] "0"    "1"    "0"    "1"    "0"    "1"    "0"    "2"    "2"    "1"   
[3051] "0"    "1"    "1"    "3"    "0"    "1"    "0"    "2"    "1"    "3"   
[3061] "1"    "0"    "0"    "0"    "1"    "1"    "1"    "1"    "2"    "1"   
[3071] "1"    "1"    "0"    "2"    "0"    "1"    "1"    "0"    "1"    "1"   
[3081] "0"    "3"    "3"    "1"    "0"    "105"  "0"    "1"    "0"    "2"   
[3091] "0"    "1"    "0"    "2"    "0"    "1"    "0"    "2"    "0"    "2"   
[3101] "0"    "2"    "0"    "2"    "1"    "5"    "1"    "0"    "0"    "0"   
[3111] "1"    "1"    "4"    "1"    "2"    "2"    "1"    "2"    "0"    "1"   
[3121] "0"    "1"    "1"    "0"    "1"    "1"    "0"    "1"    "1"    "1"   
[3131] "0"    "5"    "0"    "1"    "0"    "1"    "0"    "2"    "0"    "1"   
[3141] "1"    "5"    "2"    "2"    "2"    "2"    "0"    "1"    "0"    "2"   
[3151] "1"    "1"    "3"    "0"    "0"    "0"    "1"    "0"    "1"    "2"   
[3161] "1"    "3"    "1"    "1"    "0"    "1"    "0"    "1"    "1"    "0"   
[3171] "1"    "0"    "0"    "1"    "4"    "22"   "10"   "7"    "1"    "6"   
[3181] "5"    "65"   "11"   "1"    "2"    "8"    "5"    "4"    "7"    "12"  
[3191] "1"    "3"    "3"    "3"    "3"    "4"    "2"    "1"    "4"    "0"   
[3201] "4"    "0"    "0"    "0"    "5"    "1"    "3"    "2"    "0"    "4"   
[3211] "0"    "1"    "2"    "3"    "0"    "0"    "4"    "1"    "2"    "1"   
[3221] "0"    "2"    "1"    "1"    "0"    "1"    "0"    "6"    "4"    "1"   
[3231] "0"    "1"    "0"    "1"    "0"    "1"    "0"    "2"    "2"    "2"   
[3241] "0"    "1"    "0"    "8"    "1"    "1"    "4"    "0"    "1"    "0"   
[3251] "1"    "1"    "1"    "1"    "1"    "1"    "1"    "1"    "0"    "2"   
[3261] "0"    "1"    "1"    "0"    "1"    "1"    "0"    "1"    "14"   "22"  
[3271] "14"   "22"   "15"   "19"   "10"   "7"    "11"   "3"    "6"    "4"   
[3281] "12"   "7"    "16"   "4"    "13"   "12"   "7"    "1"    "4"    "3"   
[3291] "24"   "1"    "7"    "0"    "11"   "0"    "14"   "1"    "13"   "5"   
[3301] "12"   "3"    "1"    "1"    "6"    "4"    "2"    "7"    "1"    "0"   
[3311] "5"    "1"    "5"    "11"   "2"    "7"    "2"    "4"    "0"    "5"   
[3321] "0"    "1"    "0"    "1"    "3"    "2"    "8"    "1"    "0"    "2"   
[3331] "2"    "3"    "1"    "1"    "1"    "5"    "1"    "1"    "2"    "0"   
[3341] "4"    "0"    "1"    "1"    "2"    "1"    "1"    "9"    "3"    "1"   
[3351] "0"    "3"    "0"    "1"    "1"    "0"    "1"    "1"    "0"    "2"   
[3361] "0"    "0"    "2"    "16"   "13"   "8"    "6"    "5"    "2"    "1"   
[3371] "0"    "3"    "3"    "7"    "14"   "27"   "7"    "2"    "4"    "6"   
[3381] "14"   "3"    "15"   "10"   "3"    "2"    "7"    "0"    "6"    "0"   
[3391] "3"    "1"    "3"    "6"    "9"    "5"    "4"    "1"    "4"    "4"   
[3401] "0"    "1"    "43"   "0"    "4"    "1"    "2"    "7"    "9"    "6"   
[3411] "0"    "2"    "0"    "1"    "9"    "15"   "0"    "3"    "1"    "2"   
[3421] "0"    "3"    "0"    "3"    "5"    "2"    "2"    "1"    "1"    "4"   
[3431] "1"    "2"    "6"    "0"    "1"    "0"    "1"    "1"    "18"   "7"   
[3441] "5"    "4"    "1"    "2"    "0"    "2"    "0"    "1"    "1"    "0"   
[3451] "1"    "1"    "2"    "1"    "4"    "1"    "1"    "12"   "3"    "4"   
[3461] "1"    "1"    "4"    "1"    "4"    "3"    "6"    "4"    "0"    "4"   
[3471] "1"    "5"    "4"    "1"    "2"    "2"    "0"    "1"    "2"    "0"   
[3481] "0"    "0"    "0"    "1"    "5"    "2"    "2"    "7"    "1"    "2"   
[3491] "0"    "2"    "1"    "1"    "0"    "0"    "1"    "1"    "0"    "3"   
[3501] "0"    "0"    "3"    "2"    "0"    "1"    "0"    "1"    "2"    "2"   
[3511] "2"    "2"    "4"    "2"    "11"   "1"    "30"   "2"    "0"    "6"   
[3521] "0"    "1"    "4"    "5"    "2"    "2"    "7"    "0"    "0"    "0"   
[3531] "1"    "1"    "1"    "1"    "2"    "1"    "11"   "1"    "0"    "1"   
[3541] "9"    "1"    "5"    "0"    "1"    "1"    "0"    "9"    "5"    "3"   
[3551] "14"   "8"    "6"    "20"   "19"   "6"    "37"   "7"    "32"   "5"   
[3561] "16"   "14"   "7"    "1"    "7"    "10"   "12"   "1"    "8"    "10"  
[3571] "10"   "1"    "16"   "0"    "10"   "0"    "3"    "1"    "5"    "3"   
[3581] "2"    "1"    "4"    "2"    "1"    "2"    "0"    "1"    "2"    "0"   
[3591] "2"    "1"    "2"    "1"    "0"    "0"    "2"    "1"    "0"    "1"   
[3601] "0"    "157"  "137"  "1"    "2"    "156"  "209"  "54"   "152"  "1"   
[3611] "21"   "92"   "152"  "18"   "0"    "1"    "2"    "20"   "1854" "7"   
[3621] "1"    "0"    "0"    "0"    "1"    "1"    "2"    "1"    "1"    "1"   
[3631] "1"    "2"    "23"   "6"    "117"  "1"    "1"    "0"    "15"   "1"   
[3641] "10"   "9"    "16"   "11"   "16"   "6"    "0"    "5"    "0"    "1"   
[3651] "2"    "1"    "5"    "2"    "1"    "1"    "2"    "2"    "1"    "5"   
[3661] "0"    "3"    "0"    "2"    "3"    "2"    "9"    "0"    "8"    "0"   
[3671] "8"    "1"    "1"    "1"    "4"    "1"    "2"    "1"    "17"   "12"  
[3681] "0"    "3"    "1"    "0"    "1"    "1"    "4"    "3"    "5"    "7"   
[3691] "3"    "1"    "16"   "6"    "3"    "1"    "6"    "1"    "2"    "5"   
[3701] "5"    "2"    "0"    "4"    "2"    "4"    "3"    "10"   "0"    "2"   
[3711] "3"    "2"    "3"    "0"    "2"    "0"    "1"    "1"    "1"    "3"   
[3721] "1"    "1"    "8"    "14"   "11"   "2"    "5"    "12"   "5"    "0"   
[3731] "2"    "1"    "2"    "2"    "1"    "2"    "0"    "1"    "0"    "1"   
[3741] "0"    "1"    "0"    "2"    "0"    "2"    "0"    "9"    "0"    "2"   
[3751] "0"    "1"    "35"   "1"    "0"    "4"    "1"    "1"    "1"    "0"   
[3761] "0"    "0"    "11"   "1"    "1"    "1"    "1"    "1"    "1"    "2"   
[3771] "0"    "2"    "0"    "1"    "1"    "0"    "1"    "1"    "0"    "1"   
[3781] "19"   "9"    "7"    "11"   "10"   "4"    "18"   "8"    "2"    "1"   
[3791] "3"    "10"   "2"    "8"    "9"    "6"    "7"    "6"    "12"   "4"   
[3801] "7"    "3"    "15"   "5"    "7"    "0"    "7"    "0"    "13"   "1"   
[3811] "7"    "9"    "9"    "10"   "4"    "3"    "11"   "1"    "9"    "1"   
[3821] "2"    "0"    "5"    "1"    "11"   "6"    "5"    "1"    "5"    "1"   
[3831] "2"    "3"    "2"    "1"    "3"    "3"    "0"    "3"    "2"    "7"   
[3841] "4"    "5"    "1"    "2"    "3"    "4"    "10"   "10"   "3"    "9"   
[3851] "5"    "0"    "3"    "0"    "2"    "1"    "7"    "2"    "1"    "1"   
[3861] "1"    "1"    "3"    "4"    "1"    "3"    "7"    "0"    "3"    "1"   
[3871] "4"    "2"    "8"    "17"   "4"    "5"    "5"    "3"    "2"    "8"   
[3881] "2"    "1"    "5"    "2"    "20"   "5"    "4"    "4"    "8"    "4"   
[3891] "6"    "1"    "0"    "3"    "6"    "4"    "3"    "0"    "6"    "0"   
[3901] "8"    "1"    "4"    "8"    "2"    "2"    "1"    "3"    "5"    "4"   
[3911] "2"    "1"    "5"    "0"    "1"    "1"    "0"    "4"    "0"    "0"   
[3921] "1"    "1"    "5"    "2"    "29"   "1"    "12"   "3"    "29"   "13"  
[3931] "19"   "5"    "0"    "17"   "4"    "7"    "3"    "4"    "0"    "1"   
[3941] "0"    "4"    "51"   "2"    "1"    "0"    "2"    "0"    "1"    "1"   
[3951] "5"    "5"    "2"    "1"    "2"    "1"    "0"    "2"    "0"    "1"   
[3961] "1"    "0"    "1"    "1"    "20"   "1"    "6"    "60"   "2"    "14"  
[3971] "12"   "5"    "13"   "5"    "10"   "1"    "8"    "5"    "135"  "5"   
[3981] "9"    "3"    "3"    "2"    "8"    "2"    "4"    "1"    "5"    "3"   
[3991] "46"   "0"    "1"    "0"    "10"   "1"    "1"    "2"    "2"    "1"   
[4001] "1"    "1"    "4"    "6"    "1"    "15"   "1"    "0"    "7"    "1"   
[4011] "33"   "4"    "22"   "20"   "38"   "9"    "28"   "8"    "18"   "20"  
[4021] "1"    "10"   "9"    "13"   "12"   "7"    "6"    "9"    "0"    "5"   
[4031] "0"    "5"    "17"   "18"   "4"    "2"    "23"   "0"    "12"   "0"   
[4041] "5"    "1"    "2"    "2"    "3"    "2"    "9"    "3"    "2"    "3"   
[4051] "3"    "7"    "10"   "0"    "2"    "1"    "8"    "4"    "3"    "3"   
[4061] "7"    "9"    "10"   "3"    "2"    "3"    "5"    "3"    "5"    "2"   
[4071] "1"    "7"    "11"   "8"    "4"    "10"   "5"    "2"    "0"    "4"   
[4081] "4"    "2"    "1"    "0"    "2"    "0"    "3"    "1"    "2"    "3"   
[4091] "3"    "4"    "1"    "2"    "0"    "3"    "0"    "3"    "1"    "0"   
[4101] "3"    "1"    "0"    "1"    "0"    "0"    "3"    "1"    "3"    "1"   
[4111] "29"   "10"   "4"    "1"    "15"   "1"    "5"    "3"    "0"    "5"   
[4121] "0"    "2"    "0"    "3"    "11"   "1"    "2"    "3"    "6"    "48"  
[4131] "12"   "0"    "2"    "0"    "0"    "1"    "4"    "1"    "2"    "5"   
[4141] "16"   "2"    "0"    "2"    "12"   "3"    "4"    "0"    "0"    "1"   
[4151] "0"    "28"   "0"    "0"    "2"    "4"    "2"    "1"    "83"   "3"   
[4161] "4"    "1"    "5"    "1"    "1"    "5"    "1"    "4"    "0"    "1"   
[4171] "2"    "11"   "6"    "1"    "2"    "4"    "6"    "1"    "10"   "0"   
[4181] "21"   "0"    "0"    "0"    "1"    "3"    "0"    "2"    "0"    "2"   
[4191] "0"    "2"    "0"    "1"    "1"    "0"    "2"    "0"    "0"    "1"   
[4201] "0"    "0"    "1"    "7"    "0"    "1"    "0"    "3"    "3"    "3"   
[4211] "3"    "1"    "5"    "11"   "4"    "1"    "4"    "15"   "4"    "36"  
[4221] "0"    "29"   "2"    "3"    "5"    "1"    "1"    "0"    "2"    "0"   
[4231] "1"    "1"    "4"    "1"    "4"    "1"    "2"    "1"    "0"    "2"   
[4241] "0"    "1"    "1"    "0"    "1"    "1"    "0"    "1"    "3"    "9"   
[4251] "16"   "7"    "16"   "23"   "0"    "2"    "12"   "3"    "9"    "12"  
[4261] "10"   "9"    "11"   "2"    "5"    "3"    "8"    "3"    "8"    "12"  
[4271] "4"    "5"    "7"    "0"    "10"   "0"    "3"    "1"    "1"    "4"   
[4281] "1"    "3"    "3"    "1"    "2"    "4"    "0"    "7"    "3"    "0"   
[4291] "1"    "1"    "0"    "5"    "0"    "0"    "8"    "12"   "13"   "11"  
[4301] "3"    "10"   "12"   "4"    "11"   "8"    "13"   "10"   "7"    "5"   
[4311] "3"    "2"    "8"    "2"    "6"    "5"    "6"    "10"   "12"   "3"   
[4321] "6"    "0"    "11"   "0"    "1"    "1"    "4"    "12"   "10"   "1"   
[4331] "2"    "2"    "2"    "7"    "2"    "4"    "1"    "0"    "0"    "1"   
[4341] "2"    "1"    "0"    "0"    "2"    "3"    "0"    "3"    "0"    "1"   
[4351] "0"    "1"    "0"    "2"    "0"    "2"    "0"    "1"    "0"    "2"   
[4361] "1"    "2"    "0"    "2"    "0"    "2"    "1"    "1"    "4"    "0"   
[4371] "1"    "0"    "2"    "1"    "1"    "1"    "1"    "1"    "1"    "2"   
[4381] "0"    "2"    "0"    "1"    "1"    "0"    "4"    "1"    "0"    "1"   
[4391] "0"    "0"    "105"  "74"   "63"   "33"   "142"  "30"   "12"   "19"  
[4401] "20"   "16"   "29"   "34"   "44"   "20"   "30"   "22"   "17"   "19"  
[4411] "18"   "5"    "26"   "29"   "80"   "19"   "16"   "0"    "32"   "0"   
[4421] "35"   "1"    "19"   "21"   "51"   "36"   "26"   "7"    "67"   "24"  
[4431] "38"   "17"   "31"   "0"    "31"   "1"    "4"    "11"   "0"    "0"   
[4441] "63"   "100"  "79"   "45"   "83"   "32"   "60"   "25"   "47"   "24"  
[4451] "72"   "45"   "73"   "69"   "58"   "8"    "54"   "18"   "44"   "29"  
[4461] "55"   "37"   "56"   "25"   "26"   "0"    "32"   "0"    "50"   "1"   
[4471] "15"   "26"   "41"   "12"   "21"   "5"    "33"   "25"   "21"   "19"  
[4481] "13"   "0"    "55"   "1"    "34"   "46"   "1"    "2"    "1"    "1"   
[4491] "0"    "1"    "0"    "1"    "0"    "3"    "2"    "5"    "0"    "1"   
[4501] "0"    "2"    "1"    "1"    "0"    "1"    "0"    "2"    "0"    "1"   
[4511] "0"    "0"    "0"    "0"    "1"    "1"    "1"    "2"    "1"    "1"   
[4521] "0"    "2"    "0"    "2"    "0"    "1"    "0"    "0"    "0"    "1"   
[4531] "0"    "1"    "5"    "3"    "9"    "1"    "136"  "9"    "8"    "8"   
[4541] "0"    "4"    "10"   "16"   "36"   "77"   "11"   "13"   "0"    "13"  
[4551] "5"    "1"    "23"   "14"   "1"    "27"   "1"    "0"    "3"    "0"   
[4561] "2"    "1"    "5"    "1"    "5"    "5"    "11"   "10"   "2"    "5"   
[4571] "0"    "3"    "1"    "0"    "4"    "1"    "2"    "3"    "1"    "1"   
[4581] "2"    "6"    "4"    "1"    "0"    "1"    "0"    "12"   "0"    "1"   
[4591] "0"    "4"    "0"    "1"    "0"    "1"    "0"    "3"    "2"    "2"   
[4601] "0"    "1"    "0"    "1"    "0"    "0"    "1"    "0"    "0"    "0"   
[4611] "1"    "1"    "0"    "2"    "8"    "5"    "0"    "2"    "0"    "1"   
[4621] "9"    "0"    "2"    "0"    "0"    "1"    "3"    "1"    "3"    "5"   
[4631] "2"    "4"    "5"    "1"    "2"    "1"    "5"    "2"    "0"    "1"   
[4641] "4"    "2"    "1"    "4"    "2"    "1"    "2"    "2"    "1"    "2"   
[4651] "1"    "0"    "2"    "0"    "3"    "1"    "5"    "1"    "1"    "1"   
[4661] "5"    "2"    "0"    "2"    "0"    "3"    "1"    "0"    "1"    "1"   
[4671] "3"    "1"    "0"    "1"

Nothing seems to be strange here? This is for 100 WGS samples.