markrobinsonuzh / DAMEfinder

Finds DAMEs - Differential Allelicly MEthylated regions
MIT License
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Statistic associated with tuple ASM score #41

Closed amvondras closed 2 years ago

amvondras commented 2 years ago

I computed ASM scores for tuples in three samples.

I'm interested in knowing whether ASM is detected consistently across these replicates. Can you recommend a way to compute a test statistic for ASM in addition to the ASM score (rather than subsequently testing for gain or loss of ASM with find_dames)?

markrobinsonuzh commented 2 years ago

@amvondras

I don't know what statistical test you would want to do here, because even if replicates, you expect variability.

But, would a plot be useful, like a pairs() plot of the ASM scores across your replicates?

Mark