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martinjzhang / scDRS

Single-cell disease relevance score (scDRS)
https://martinjzhang.github.io/scDRS/
MIT License
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Sig. cell type-disease associations and Sig. individual cells #104

Closed hopehan12 closed 2 months ago

hopehan12 commented 2 months ago

Hi Martin,

Thanks for the great work! I finished the analysis and I am kinda stuck with interpreting the results. I have 0 significant individual cells (0 out of 252452 cells) but significant cell type-disease associations in some cell types (2 out of 12 cell types). I am wondering if this is because of generally higher disease scores across cells within that cell type?

Please just let me know, many thanks!

martinjzhang commented 2 months ago

You are correct. Cell type-level analysis can be more powerful if cells within a cell type have consistently higher disease scores (which may not be significant for individual disease cells).

martinjzhang commented 2 months ago

We plan to release a significantly more powerful version in a few months. Stay tuned.

hopehan12 commented 2 months ago

Hi Martin, Thank you! Super helpful. I will keep an eye out for it!