Some users may use all scRNA-seq genes as the trait gene set as some sort of negative control. scDRS produced miscalibrated results in this case due to numerical issues.
Raw control scores were slightly but systematically smaller than the disease score (1e-17).
Small SD of raw control of a given cell across control gene sets (1e-18).
Some users may use all scRNA-seq genes as the trait gene set as some sort of negative control. scDRS produced miscalibrated results in this case due to numerical issues.