Fix the code in AMBIndicator/calculateIndicatorPositionForTarget to correctly calculate coordinates when the target is in all directions. Right now it's really just working in the top right.
Calculate rotation of the sprite so the arrow points in the right direction always.
Add some padding around the screen so it's not right at the edge.
Design on-screen indicators for active patients and hospitals so the player can find their way around.
http://gamedevelopment.tutsplus.com/tutorials/positioning-on-screen-indicators-to-point-to-off-screen-targets--gamedev-6644