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metrumresearchgroup / lastdose

Fast computation of [time since] and [amount of] the most-recent dose in a data set
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Choose how TAD and LDOS are filled #3

Closed kylebaron closed 4 years ago

kylebaron commented 5 years ago

Summary

As a user, I want to be able to choose how TAD and LDOS are filled/entered in the dataset.

Tests

barrettk commented 2 years ago

Notes:

  1. By default, doses prior to the first dosing record will be calculated as time before the first dose and be expressed as negative numbers.
  2. The user may choose to fill in TAD for records prior to the first dose with a single user-specified fill value.
  3. The user can choose how to handle TAD when additional doses (via ADDL happen at the same time as another record in the data set. By default, records at the same time are sorted ascending by dose amount so that observation records happen prior to doses. This makes the observation a trough concentration. Alternatively, records can be sorted descending by dose amount so that doses happen first. This makes the observation a peak. The sorting that is done has no bearing on records explicitly listed in the input data.