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meyer-lab / DrugResponseModel.jl

This is to show oscillations in the number of cells in G1 and in G2 phase of cell cycle.
MIT License
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modify cell death term in the ODE model #478

Closed Farnazmdi closed 1 year ago

Farnazmdi commented 3 years ago

@aarmey I thought a little about how to modify the death rates, but I guess if we don't want to mess with the Jacobian matrix, we should still have a "rate". Did you have a specific form of a death rate parameter in mind? I guess if we want to make it a probability, then we need a term outside of the Jacobian matrix and it may make solving it harder?

Or did you want me to change the way we apply the Hill on death rates?

aarmey commented 3 years ago

Yes, you have to modify the model/Jacobian.

aarmey commented 3 years ago

You want to try having only one rate of progression, but then separately a probability of progression vs. death.