glomerular filtration barrier

[obophenotype-user]

Please add:

1. abnormal glomerular filtration barrier morphology SYN: abnormal GFB morphology DEF: any structural anomaly of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte)

2. abnormal glomerular filtration barrier function SYN: abnormal GFB permeability DEF: anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman's space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine

Thanks

Anna

Reported by: anna_anagnos

Original Ticket: obo/mammalian-phenotype-requests/1279

[obophenotype-user]

New terms added:

abnormal glomerular filtration barrier morphology MP:0011855

abnormal glomerular filtration barrier function MP:0011856

Original comment by: cindyJax

[obophenotype-user]

• assigned_to: nobody --> cynthiasmith
• status: open --> closed-accepted

Original comment by: cindyJax