obophenotype-user
commented
16 years ago Perhaps including terms that specify specific classes of inducers has been a mistake. Including specific inducers in term names is probably beyond the scope of the MP. However, I do think that the terms "abnormal induced cell death" etc are appropriate. For now, I will add these new terms and then reconsider whether or not to merge and/or obsolete the terms that contain specific inducers.
Terms added:
abnormal induced cell death MP:0008942 increased sensitivity to induced cell death MP:0008943 decreased sensitivity to induced cell death MP:0008944
Original comment by: cindyJax
We have several terms under cell death for increased or decreased sensitivity to specific classes of inducers. However, I have worked on 2 papers (J:16558 & 136554) today that use agents not in any of the existing classes. I think it would be helpful to add the terms: abnormal induced cell death child of abnormal cell death definition - anomaly in the response to an agent that induces cessation of function at the cellular level
increased sensitivity to induced cell death child of abnormal induced cell death definition - decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level
decreased sensitivity to induced cell death child of abnormal induced cell death definition - increase in the exposure level to an agent that is required to induce cessation of function at the cellular level
The existing increased and decreased cellular sensitivity terms would then fall under these new terms.
Even with the addition of these terms I'll end up double annotating the phenotypes in these papers to decreased sensitivity to induced cell death and decreased sensitivity to xenobiotics. We may want to consider adding the terms increased sensitivity to xenobiotic induced cell death and decreased sensitivity to xenobiotic induced cell death. These terms could be problematic since some of the existing cellular sensitivity terms are defined by the agents mechanism of action (oxidative stress, alkylating) rather than the type of agent. Although others are defined by the type of agent (UV, ionizing radiation). At some point we will run into agents that fall under more than 1 term.
Reported by: sbello
Original Ticket: "obo/mammalian-phenotype-requests/14":https://sourceforge.net/p/obo/mammalian-phenotype-requests/14