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Standard terms for annotating mammalian phenotypic data
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increased urinary mineral level synonyms #1414

Closed obophenotype-user closed 8 years ago

obophenotype-user commented 11 years ago

Consider adding the synonym X wasting for the terms increased urine calcium level (i.e. calcium wasting) increased urine magnesium level increased urine potassium level See J:159706 for calcium and magnesium See OMIM (241200 and others) for potassium also http://www.nlm.nih.gov/medlineplus/ency/article/000308.htm Medline Plus article

Reported by: sbello

Original Ticket: obo/mammalian-phenotype-requests/1414

obophenotype-user commented 11 years ago

HPO has a term called Renal Potassium wasting (undefined). So we may want to make the synonym renal X wasting

Original comment by: sbello

obophenotype-user commented 11 years ago

Dear Sue and colleagues,

I have provided a definition for renal potassium wasting. This is something that is measured in certain medical contexts:

Definition: High urine potassium in the presence of hypokalemia. Comment: A urine potassium assay can be used to determine the cause of reduced serum potassium (hypokalemia). Normally, the kidney will reabsorb more potassium in the presence of hypokalemia. Therefore, a low urine potassium can suggest gastrointestinal potassium loss, poor dietary intake, or a shift of potassium from the extracellular to the intracellular space. On the other hand, a high urine potassium in the face of low serum potassium indicated renal loss, referred to as renal potassium wasting.

So therefore the terms are not synonymous. I see that the HPO hierarchy in this section could use with a bit of revision, perhaps the MP and the HP could group up to make sure there are correct correspondences wherever possible?

-Peter

Dr. med. Peter N. Robinson, MSc. Professor of Medical Genomics Professor in the Bioinformatics Division of the Department of Mathematics and Computer Science of the Freie Universität Berlin Institut für Medizinische Genetik und Humangenetik Charité - Universitätsmedizin Berlin Augustenburger Platz 1 13353 Berlin Germany +4930 450566006 Mobile: 0160 93769872 peter.robinson@charite.de http://compbio.charite.de http://www.human-phenotype-ontology.org Introduction to Bio-Ontologies: http://www.crcpress.com/product/isbn/9781439836651 I have learned from my mistakes, and I am sure I can repeat them exactly ORCID ID:http://orcid.org/0000-0002-0736-9199 Scopus Author ID 7403719646

Von: Sue Bello [suebello@users.sf.net] Gesendet: Mittwoch, 2. Oktober 2013 22:34 An: [obo:mammalian-phenotype-requests] Betreff: [obo:mammalian-phenotype-requests] #1414 increased urinary mineral level synonyms

HPO has a term called Renal Potassium wasting (undefined). So we may want to make the synonym renal X wasting

[mammalian-phenotype-requests:#1414]http://sourceforge.net/p/obo/mammalian-phenotype-requests/1414/ increased urinary mineral level synonyms

Status: open Labels: new synonym request Created: Wed Oct 02, 2013 08:32 PM UTC by Sue Bello Last Updated: Wed Oct 02, 2013 08:32 PM UTC Owner: nobody

Consider adding the synonym X wasting for the terms increased urine calcium level (i.e. calcium wasting) increased urine magnesium level increased urine potassium level See J:159706 for calcium and magnesium See OMIM (241200 and others) for potassium also http://www.nlm.nih.gov/medlineplus/ency/article/000308.htm Medline Plus article

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Original comment by: pnrobinson