obophenotype-user
commented
10 years ago added terms: MP:0020121 abnormal tyrosine 3-monooxygenase activity MP:0020122 decreased tyrosine 3-monooxygenase activity MP:0020123 increased tyrosine 3-monooxygenase activity
Original comment by: nicolevasilevsky
Proposed new hierarchy MP:0005584 abnormal enzyme/ coenzyme activity -i- abnormal tyrosine 3-monooxygenase activity --i-- MP:NEW decreased tyrosine 3-monooxygenase activity --i-- MP:NEW increased tyrosine 3-monooxygenase activity
defs: abnormal tyrosine 3-monooxygenase activity def: anomaly in the ability to catalyze the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. Source: http://enzyme.expasy.org/EC/4.1.1.53 Syn: abnormal tyrosine hydroxylase activity
decreased tyrosine 3-monooxygenase activity def: decreased ability to catalyze the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. Source: http://enzyme.expasy.org/EC/4.1.1.53 Syn: decreased tyrosine hydroxylase activity
increased tyrosine 3-monooxygenase activity def: increased ability to catalyze the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. Source: http://enzyme.expasy.org/EC/4.1.1.53 Syn: increased tyrosine hydroxylase activity
Reported by: nicolevasilevsky
Original Ticket: obo/mammalian-phenotype-requests/1625