search

mgijax / mammalian-phenotype-ontology

Standard terms for annotating mammalian phenotypic data
Creative Commons Attribution 4.0 International
19 stars 6 forks source link

abnormal nocifensive behavior #1672

Open obophenotype-user opened 10 years ago

obophenotype-user commented 10 years ago

J:200749 talks about changes in abnormalities in nocifensive behavior after UV exposure. We do not have any terms for nocifensive behavior. I found a definition of nocifensive behavior here http://www.therapyofpain.com/nocifensive-behavior.htm. This seems like it should be under abnormal sensory capabilities/reflexes/nociception. I think we can't put it under abnormal touch/ nociception since then it would end up under integument as well as behavior.

Reported by: sbello

Original Ticket: obo/mammalian-phenotype-requests/1672

obophenotype-user commented 10 years ago

Some thoughts to define the difference:

nociceptive includes sensory, cognitive

nocifensive includes motor-action, audible vocalizations and spinal reflexes

Original comment by: cindyJax

sbello commented 8 years ago

See https://books.google.com/books?id=9LpxCwGcV6oC&pg=PA334&lpg=PA334&dq=nocifensive+vs+nociceptive&source=bl&ots=ity_VclZNc&sig=7KUV2_N3ipyO4QtWa_L7JNrqUgw&hl=en&sa=X&ved=0ahUKEwiu8dbE64LPAhWD2T4KHRJcAwQQ6AEILzAC#v=onepage&q=nocifensive%20vs%20nociceptive&f=false nocifensive behaviors may be displayed in the absence of nociceptive signals, also need to distinguish nociception from pain

sbello commented 8 years ago

Currently we have nociception terms under behavior and integument but I'm not sure either of these is correct. Nociceptors may be found in tissues other than skin and most of the nociception terms are defined as ability to sense a stimulus rather than a behavioral response to a stimulus. See PMID:27322240 http://www.mdpi.com/1420-3049/21/6/797/htm PMID:26690128 http://www.mdpi.com/1422-0067/16/12/26151/htm "Nociceptors innervate target tissue in muscles, joints, the digestive tract, and several internal organs, where they transduce noxious physical sensations into neural impulses that are transmitted along the cell’s axon to the dorsal horn of the spinal cord" PMID:26543372 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624094/ UBERON has nociceptors under nervous system (UBERON:0035017). I'm thinking we need to rework this to move actual function of nociceptors to be under nervous system and separate behavioral responses to nociception into separate terms. For now I've added the term: abnormal nocifensive behavior as a child of abnormal behavior MP:0020374