enteric neural crest cell

[obophenotype-user]

See open ticket #893

Please add:

abnormal enteric neural crest cell morphology DEF: any structural anomaly of the neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; neural crest cells are termed enteric neural crest-derived cells upon entering the foregut at E9–9.5 in mice (after 4 weeks gestation in humans) SYN: abnormal enteric neural crest-derived cell morphology SYN: abnormal ENCC morphology SYN: abnormal ENCDC morphology From J:108439 J:116089

DEFINITION SOURCES: (1) Enteric neural crest-derived cells promote their migration by modifying their microenvironment through tenascin-C production. Dev Biol. 2013 Oct 15;382(2):446-56. doi: 10.1016/j.ydbio.2013.08.006. PMID: 23958436

(2) Enteric nervous system development and Hirschsprung’s disease: advances in genetic and stem cell studies. Nature Reviews Neuroscience 8, 466-479 (June 2007) doi:10.1038/nrn2137

abnormal enteric neural crest cell proliferation DEF: any anomaly in the ability of the enteric neural crest cells to undergo rapid expansion by cell division SYN: abnormal enteric neural crest-derived cell proliferation SYN: abnormal ENCC proliferation SYN: abnormal ENCDC proliferation

decreased enteric neural crest cell proliferation DEF: reduced ability of the enteric neural crest cells to undergo rapid expansion by cell division SYN: decreased enteric neural crest-derived cell proliferation SYN: decreased ENCC proliferation SYN: decreased ENCDC proliferation SYN: reduced enteric neural crest cell proliferation SYN: reduced enteric neural crest-derived cell proliferation SYN: reduced ENCC proliferation SYN: reduced ENCDC proliferation From J:190742

decreased enteric neural crest cell number DEF: a reduction in the number of neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut SYN: decreased enteric neural crest-derived cell number SYN: decreased ENCC number SYN: decreased ENCDC number SYN: reduced enteric neural crest cell number SYN: reduced enteric neural crest-derived cell number SYN: reduced ENCC number SYN: reduced ENCDC number From J:153219, J:190742

absent enteric neural crest cell(s) DEF: absence or loss of the neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut SYN: absent enteric neural crest-derived cell(s) SYN: absent ENCCs SYN: absent ENCDCs From J:71588, J:102170

Thanks

Anna

Reported by: anna_anagnos

Original Ticket: obo/mammalian-phenotype-requests/1686

[obophenotype-user]

• status: open --> closed-accepted
• assigned_to: Cynthia Smith
• Group: -->

Original comment by: cindyJax

[obophenotype-user]

abnormal enteric neural crest cell morphology MP:0013001 decreased enteric neural crest cell number MP:0013002 absent enteric neural crest cell MP:0013003 abnormal enteric neural crest cell proliferation MP:0013004 decreased enteric neural crest cell proliferation MP:0013005

Original comment by: cindyJax