pineal gland terms

[obophenotype-user]

Consider modifying the definition of abnormal pineal gland morphology [MP:0000632] to read as:

abnormal pineal gland morphology [MP:0000632] SUGGESTED DEF: any structural anomaly of the unpaired epithalamic structure that is shaped like a tiny pine cone and located above the posterior commissure near the level of the habenular complex and the sylvian aqueduct; it is both a circumventricular organ and an endocrine organ that secretes melatonin, a serotonin-derived hormone involved in the regulation of circadian rhythms; the pineal parenchyma, consisting of pinealocytes, interstitial (glial-like) cells, phagocytes and capillaries, is arranged into large folliculi separated by septae of connective tissue and blood vessels ADD NEW SYN: abnormal conarium morphology

abnormal pinealocyte morphology DEF: any structural anomaly of the principal cell of the pineal gland, characterized by two or more long cell processes ending in bulbous expansions that terminate in perivascular spaces surrounding capillaries; pinealocytes are secretory cells organized into cords and clusters resting on a basal lamina and surrounded by connective tissue, blood vessels lined by fenestrated endothelial cells, and nerves; their cytoplasm contains abundant mitochondria and multiple synaptic ribbons that are randomly distributed; the primary function of the pinealocytes is the secretion of melatonin; pinealocytes receive a direct innervation from sympathetic neurons that form recognizable synapses SYN: abnormal pineocyte morphology SYN: abnormal pinocyte morphology SYN: abnormal pineal parenchymal cell morphology SYN: abnormal chief cell of corpus pineale SYN: abnormal parenchymatous cell of corpus pineale

abnormal pineal recess morphology DEF: any structural anomaly of the diverticulum of the thin roof of the dorsocaudal third ventricle that projects into the stalk of the pineal gland SYN: abnormal recessus pinealis morphology

absent pineal recess DEF: absence of the diverticulum of the thin roof of the dorsocaudal third ventricle that projects into the stalk of the pineal gland SYN: absent recessus pinealis J:184232

absent pineal gland DEF: absence of the unpaired epithalamic structure that is shaped like a tiny pine cone and located above the posterior commissure near the level of the habenular complex and the sylvian aqueduct; the pineal is both a circumventricular organ and an endocrine organ that secretes melatonin, a serotonin-derived hormone involved in the regulation of circadian rhythms SYN: absent conarium SYN: absent epiphysis cerebri SYN: absent glandula pinealis SYN: absent pineal body SYN: apinealism J:5049, J:184232

abnormal pineal gland development DEF: aberrant formation or incomplete differentiation of the pineal gland which normally develops from a saccular outpocketing of the posterior diencephalic roof in the midline of the third ventricle; continued diverticulation and infolding result in a solid parenchymal mass of cords and clusters of pinealocytes and glial-like interstitial cells supported by a meninges-derived connective tissue that carries blood vessels and nerves to the pineal gland SYN: abnormal pineal development SYN: abnormal conarium development DEF SOURCE: https://www.inkling.com/read/histology-cell-biology-kierszenbaum-tres-3rd/chapter-18/pineal-gland

enlarged pineal gland DEF: increased size of the unpaired epithalamic structure that is shaped like a tiny pine cone and located above the posterior commissure near the level of the habenular complex and the sylvian aqueduct; the pineal is both a circumventricular organ and an endocrine organ that secretes melatonin, a serotonin-derived hormone involved in the regulation of circadian rhythms SYN: enlarged conarium SYN: enlarged epiphysis cerebri SYN: enlarged glandula pinealis SYN: enlarged pineal body SYN: increased pineal gland size SYN: increased pineal body size J:60231

increased pineal gland tumor incidence as a child of "increased brain tumor incidence [MP:0009277]" DEF: greater than the expected number of neoplams in the pineal gland occurring in a specific population in a given time period SYN: increased pineal body tumor incidence SYN: pineal tumor SYN: pinealoma J:60231

Thanks

Anna

Reported by: anna_anagnos

Original Ticket: obo/mammalian-phenotype-requests/1884

[obophenotype-user]

• status: open --> closed-accepted
• assigned_to: Cynthia Smith
• Group: -->

Original comment by: cindyJax

[obophenotype-user]

modified definition of abnormal pineal gland morphology [MP:0000632] and added new syn new terms added: abnormal pinealocyte morphology MP_0013359 abnormal pineal recess morphology MP_0013360 absent pineal recess MP_0013361 absent pineal gland MP_0013362 abnormal pineal gland development MP_0013363 enlarged pineal gland MP_0013364 increased pineal gland tumor incidence MP_0013365

Original comment by: cindyJax