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Standard terms for annotating mammalian phenotypic data
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new term request: sex ratio distortion #2650

Open LaurensWilming opened 6 years ago

LaurensWilming commented 6 years ago

If this is a request for a new term, please provide us with the following information.

  1. Preferred term label

sex ratio distortion

  1. Textual definition

deviation from expected gender ratio in the frequency that an allele or haplotype appears in the offspring of an organism

  1. Suggested parent term (Please look in the hierarchy of the MP using the [MP Browser]

MP:0001929 abnormal gametogenesis

Also: the current description of the related MP:0004179 transmission ratio distortion term should probably be changed to deviation from expected Mendelian ratios in the frequency that an allele or haplotype appears in the offspring of an organism. The current description appears a bit muddled/crooked.

Thanks, Laurens

sbello commented 6 years ago

Hi Laurens, Would you please provide a reference. I'd like to make sure this is due to gametogenesis and not the result of preferential loss of offspring of one sex vs the other. Thanks, Sue

sbello commented 6 years ago

There is a broader issue of how to better capture phenotypes with a sex bias in incidence or severity. We have a number of annotations referring to this phenomena. See PMID:26616005 PMID:18818193 PMID:12917331. Unlike cases where we use M/F the phenotype occurs in both sexes.

LaurensWilming commented 6 years ago

From: Sue Bello notifications@github.com<mailto:notifications@github.com> Reply-To: obophenotype/mammalian-phenotype-ontology reply@reply.github.com<mailto:reply@reply.github.com> Date: Tuesday, 16 January 2018 at 16:11 To: obophenotype/mammalian-phenotype-ontology mammalian-phenotype-ontology@noreply.github.com<mailto:mammalian-phenotype-ontology@noreply.github.com> Cc: Laurens Wilming laurens.wilming@jax.org<mailto:laurens.wilming@jax.org>, Author author@noreply.github.com<mailto:author@noreply.github.com> Subject: Re: [obophenotype/mammalian-phenotype-ontology] new term request: sex ratio distortion (#2650)

Hi Laurens, Would you please provide a reference. I'd like to make sure this is due to gametogenesis and not the result of preferential loss of offspring of one sex vs the other. Thanks, Sue J:243444. They do not specify if fewer females are born, but say that at 2 weeks, fewer survived. The phenotype is actually male sterility. So maybe maybe gametogenesis is not the best place to put this. Maybe better somewhere else and broaden its scope to include sex-specific survivability.

Cheers, Laurens

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Dr Laurens Wilming Alleles & Phenotypes Curator Mouse Genome Informatics The Jackson Laboratory 600 Main Street Bar Harbor, ME 04609, USA www.jax.org

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