New term request: abnormal transcription

[LaurensWilming]

If this is a request for a new term, please provide us with the following information.

1. Preferred term label

abnormal transcription

3. Textual definition

any anomaly in the cellular process where a DNA sequence template is transcribed into mRNA molecules that act as a substrate for protein translation

4. Any additional notes to clarify the meaning or use of the term. Please provide a PubMed ID or URL(s) for the source of this information.

PMID:27040500 discusses NMD (nonsense-mediated decay of mRNA transcripts). Under Abnormal Cell Physiology there are terms for protein translation and DNA-related terms, but none for mRNA/transcription.

5. Suggested parent term

MP:0005621 abnormal cell physiology

[sbello]

added MP:0020845

[sbello]

reviewing other annotations to abnormal cell physiology to see if additional terms are needed

[sbello]

added MP:0020846 0 abnormal cell motility

[sbello]

other potential terms: abnormal peroxisome physiology abnormal exocytosis (GO:0006887) abnormal cellular immortalization (GO:0020021, possibly broader than the GO term as this may be done using proteins and not necessarily a virus) abnormal ATP level abnormal actin filament morphology (GO:0005884) abnormal cellular response to stress (GO:0033554) - example stressors - thermal, tunicamycin or thapsigargin or genotoxic, laminar shear, hypotonic, hyperosmotic, NaCl or urea abnormal vacuole morphology (GO:0005773 ) - a number of annotations for vacuole accumulation are under physiology but these should probably be under morphology

[sbello]

abnormal peroxisome physiology MP:0020847 abnormal exocytosis MP:0020848 abnormal actin cytoskeleton morphology MP:0020849 abnormal microtubule cytoskeleton morphology MP:0020850

[sbello]

abnormal vacuole morphology MP:0020851