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mgijax / mammalian-phenotype-ontology

Standard terms for annotating mammalian phenotypic data
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Von Willebrand factor levels #3294

Closed anna-anagnostop closed 4 years ago

anna-anagnostop commented 4 years ago

We need terms for abnormal, increased and decreased circulating Von Willebrand factor levels

abnormal circulating von Willebrand factor level (a child of abnormal circulating protein level MP:0005416) DEF: any anomaly in the blood plasma level of the large multimeric glycoprotein produced by vascular endothelial cells and megakaryocytes that chaperones blood coagulation cofactor factor VIII and tethers platelets to the injured blood vessel wall SYN: abnormal plasma Von Willebrand factor level SYN: abnormal plasma VWF level SYN: abnormal circulating VWF level SOURCE: PMID:29507883

decreased circulating von Willebrand factor level DEF: reduced blood plasma level of the large multimeric glycoprotein produced by vascular endothelial cells and megakaryocytes that chaperones blood coagulation cofactor factor VIII and tethers platelets to the injured blood vessel wall SYN: decreased plasma von Willebrand factor level SYN: decreased plasma VWF level SYN: reduced circulating VWF level SYN: reduced plasma von Willebrand factor level SYN: reduced plasma VWF level

increased circulating von Willebrand factor level DEF: elevated blood plasma level of the large multimeric glycoprotein produced by vascular endothelial cells and megakaryocytes that chaperones blood coagulation cofactor factor VIII and tethers platelets to the injured blood vessel wall SYN: increased plasma von Willebrand factor level SYN: increased plasma VWF level SYN: increased circulating VWF level

NOTE TO SELF: check J:12434 and annotations under abnormal circulating protein level MP:0005416

anna-anagnostop commented 4 years ago

Added new terms: abnormal circulating von Willebrand factor level MP:0031163 decreased circulating von Willebrand factor level MP:0031164 increased circulating von Willebrand factor level MP:0031165