Closed slaulederkind closed 3 years ago
See https://en.wikipedia.org/wiki/Cerebral_circulation
CBF is defined as the volume of arterial blood delivered to a unit mass of brain tissue per unit of time. PMID: 29693564
CBF is defined as the blood volume that flows per unit mass per unit time in brain tissue and is typically expressed in units of mlblood/(100 gtissue min). Alternatively, one may express CBF in terms of flow per unit volume of brain tissue, thus in mlblood/(100 mltissue min). The numerical values of CBF in the two cases differ by a factor given by the density of human brain tissue, which is about 1.04 to 1.06 g/ml (with reported values, measured ex vivo, as high as 1.08 g/ml).4 The normal average cerebral blood flow (CBF) in adult humans is about 50 ml/(100 g min),5 with lower values in the white matter [∼20 ml/(100 g min)] and greater values in the gray matter [∼80 ml/(100 g min)]. PMID: 27403447
unclear if cerebrum is being used as a synonym for the brain in general, suggest creating a generic brain blood flow rate term and then create a specific cerebrum as child
I need specific cerebrum terms for blood flow in the cerebral hemispheres. Making "brain" parent terms might save you more work later if the "brain" terms would be needed later for some other curation. Thanks.
@slaulederkind that is our plan (create both) since some existing MGI annotations are unclear
Added new terms:
abnormal brain blood flow rate MP:0031179 decreased brain blood flow rate MP:0031180 increased brain blood flow rate MP:0031181 abnormal cerebral blood flow rate MP:0031182 decreased cerebral blood flow rate MP:0031183 increased cerebral blood flow rate MP:0031184
Still need to decide on what EQs to use; Also, check EQs for abnormal coronary flow rate and abnormal renal plasma flow rate terms
For decreased terms use abnormallyDecreasedRateOfBiologicalProcessInLocation.yaml:
'has_part' some ('decreased rate' and ('inheres_in' some (%s and ('occurs_in' some %s))) and ('qualifier' some 'abnormal'))
For increased terms use abnormallyDecreasedRateOfBiologicalProcessInLocation.yaml:
'has_part' some ('increased rate' and ('inheres_in' some (%s and ('occurs_in' some %s))) and ('qualifier' some 'abnormal'))
Added EQs for abnormal coronary flow rate and abnormal renal plasma flow rate terms
Also, amended EQs for abnormal coronary circulation MP:0006111 and abnormal pulmonary circulation MP:0002295 using:
'has_part' some ('process quality' and ('inheres_in' some (%s and ('occurs_in' some %s))) and ('has_modifier' some 'abnormal'))"
ORCID:0000-0001-9196-0135