sbello
commented
3 years ago alt def: deviation from the normal levels of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3; it is involved in a variety of processes including chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects, and plays an important role during viral infections by stimulating the activation and migration of immune cells to infected sites
anna-anagnostop
Need new term:
abnormal CXCL10 level (a child of abnormal chemokine level MP:0008721) DEF: deviation from the normal levels of this pro-inflammatory cytokine that is secreted by a wide range of cell types (including monocytes, neutrophils, endothelial cells and fibroblasts) in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3; CXCL10 is a chemoattractant for monocytes/macrophages, T cells, dendritic cells, and NK cells; promotes T cell adhesion to endothelial cells; is a mitogenic and chemotactic factor for vascular smooth muscle cells; and plays roles in antitumor activity, bone marrow colony formation, and angiogenesis SYN: abnormal C-X-C motif chemokine ligand 10 level SYN: abnormal IFN gamma-inducible protein 10 level SYN: abnormal interferon gamma-induced protein 10 level SYN: abnormal gamma-IP10 level SYN: abnormal small-inducible cytokine B10 level SYN: abnormal IP-10 level SYN: abnormal IP10 level SOURCE: PMID:24642726, https://www.prospecbio.com/ip-10
Also, create:
increased/decreased child terms of abnormal CXCL10 level
abnormal circulating CXCL10 level (a child of abnormal circulating chemokine level MP:0010209) and increased/decreased circulating child terms
abnormal CXCL10 secretion (a child of abnormal chemokine secretion MP:0008722 ) and increased/decreased secretion child terms
NOTE: Alternative def of CXCL10 UPKB:P02778 DEF: pro-inflammatory cytokine involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects; it plays an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites SOURCE: https://www.uniprot.org/uniprot/P02778, UniProtKB - P02778 (CXL10_HUMAN)