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mgijax / mammalian-phenotype-ontology

Standard terms for annotating mammalian phenotypic data
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abnormal adipose tissue noradrenaline turnover #3471

Closed slaulederkind closed 2 years ago

slaulederkind commented 3 years ago

If this is a request for a new term, please provide us with the following information.

  1. Preferred term label (e.g., asplenia)

a. abnormal adipose tissue noradrenaline turnover b. decreased adipose tissue noradrenaline turnover c. increased adipose tissue noradrenaline turnover

  1. Synonyms (e.g., absent spleen)

a. abnormal adipose tissue norepinephrine turnover b. decreased adipose tissue norepinephrine turnover c. increased adipose tissue norepinephrine turnover

  1. Textual definition (the definition should be understandable even for non-specialists. Include a PubMed ID or URL(s) to refer to any relevant article(s) that provides information about the suggested term).

a. aberrant level of turnover of the hormone secreted by the adrenal medulla and neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS b. reduced level of turnover of the hormone secreted by the adrenal medulla and neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS c. higher level of turnover of the hormone secreted by the adrenal medulla and neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS

PMID:23555928

  1. Any additional notes to clarify the meaning or use of the term. Please provide a PubMed ID or URL(s) for the source of this information.

  2. Suggested parent term (Please look in the hierarchy of the MP using the MP Browser or other browsers such as OLS and find the place in the MP where the new term best fits)

a. abnormal noradrenaline level (MP:0003964) b. abnormal adipose tissue noradrenaline turnover (new term) c. abnormal adipose tissue noradrenaline turnover (new term)

  1. If you would like a nanoattribution, please indicate your ORCID id or provide a label such as MGI:sbello (organization, first initial-last name)

ORCID:0000-0001-9196-0135

anna-anagnostop commented 3 years ago

Per PMID:23555928, adipose tissue noradrenaline (norepinephrine, NE) turnover (NETO) is a neurochemical index of sympathetic activation (drive) in adipose tissue. See https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/56895/1/JJVR_62.3%20p.117-127.pdf and https://doi.org/10.1152/ajpregu.00368.2006 for calculation of NETO. Fractional turnover rates of NE are measured based on the rate of decline in tissue NE content after inhibition of catecholamine biosynthesis (with α-methyl-p-tyrosine, AMPT ). AMPT inhibits tyrosine hydroxylase and prevents reaccumulation of NE, which is released in response to neural stimuli. The endogenous organ levels then decline at a rate proportional to the initial NE concentration. When the log of NE is plotted against time, the straight line provides the fractional turnover rate (k).

anna-anagnostop commented 3 years ago

See also abnormal neurotransmitter turnover #3349, closed. Reopen issue to amend definition: abnormal neurotransmitter turnover MP:0020970 DEF: any anomaly in the process by which neurotransmitters are renewed, frequently measured as a ratio of metabolite(s) of the neurotransmitter to the neurotransmitter itself

abnormal adipose tissue noradrenaline turnover (a child of abnormal neurotransmitter turnover and DEF: any anomaly in the process by which noradrenaline is renewed, frequently measured as a ratio of metabolite(s) of noradrenaline to noradrenaline itself

sbello commented 2 years ago

kicked neurotransmitter turnover out of nervous system placed under homeostasis

sbello commented 2 years ago

We did not have neurotransmitter turnover under neurotransmitter level. should it be or do we not put this term under level?

GO has a few turnover terms "tRNA end turnover" and "peptidoglycan turnover" that are placed under metabolic process. Given that the turnover phenotypes are related to similar processes should this be under metabolism? Or since it is indirect and equivalent to the ratio of levels is it better under homeostasis? For now I've moving this under metabolism as the definition specifies the process by which X is renewed then mentions the measurement.

sbello commented 2 years ago

MP:0021021 - abnormal MP:0021022 - decreased MP:0021023 - increased child of abnormal metabolism and abnormal adipose tissue physiology