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mgijax / mammalian-phenotype-ontology

Standard terms for annotating mammalian phenotypic data
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sperm tail outer dense fibers #3505

Closed anna-anagnostop closed 2 years ago

anna-anagnostop commented 2 years ago

Add new term: abnormal outer dense fiber morphology (as a child of abnormal sperm flagellum morphology MP:0008892) See PMID: 7378538 and PMID: 29168316 for definition

anna-anagnostop commented 2 years ago

abnormal outer dense fiber morphology SUGGESTED DEF: any structural anomaly of the highly condensed, modified intermediate cytoskeletal filaments strengthened by disulfide linked keratin proteins that progress from the midpiece to the principal piece of the sperm tail, generating a 9 + 9 + 2 cross‐sectional pattern; each outer dense fiber (ODF), numbered from 1 to 9 according to differences in cross‐sectional shape and size, connects with one microtubular doublet of the axoneme; in the principal piece, the fibrous sheath replaces ODFs 3 and 8, and the sizes of other ODFs progressively decrease distally SYN: abnormal ODF morphology SOURCE: PMID: 29168316, https://royalsocietypublishing.org/doi/10.1098/rsif.2018.0668

Comment: The shapes, sizes and lengths of ODFs are quite distinct in different species. ODFs are believed to maintain flagellar elasticity and play a role in the protection of the sperm tail against shear forces during epididymal transport and ejaculation PMID: 29168316

anna-anagnostop commented 2 years ago

Added new term: abnormal outer dense fiber morphology MP:0031356