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mgijax / mammalian-phenotype-ontology

Standard terms for annotating mammalian phenotypic data
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cardiac endothelial cell terms #3696

Open anna-anagnostop opened 1 year ago

anna-anagnostop commented 1 year ago

Question from Monika 11/16/2022

"Paper I’m working on is looking at primary mouse cardiac endothelial cells from hearts…they have some cellular abnormalities, as well as decreased directional migration. We don’t have a cardiac endothelial cell MP term and I’m wondering if the vascular endothelial cell terms would be correct to use. What are your thoughts on what MP terms to use for this annotation?"

sbello commented 1 year ago

Given the definition of the MP term as "cells that line the vasculature" and the fact that CL has separate terms for "cardiac endothelial cell" and "endothelial cell of vascular tree" and these are siblings under endothelial cell http://purl.obolibrary.org/obo/CL_0000115) I would say not to use the vascular term. For annotations now I think you would have to go with cardiac terms or cell migration. We should consider creating generic endothelial cell terms and some cardiac specific ones.

anna-anagnostop commented 1 year ago

FYI, The paper Monika is working on is J:310382, PMID:24451259.

sbello commented 1 year ago

Poking a bit more, she could use abnormal endocardium morphology (MP:0003974) for the morphology annotations as this is defined as "any structural anomaly of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" There are a couple of annotations to this term already that talk about endothelial cell abnormalities