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mgijax / mammalian-phenotype-ontology

Standard terms for annotating mammalian phenotypic data
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sexual impotence #4006

Closed anna-anagnostop closed 2 months ago

anna-anagnostop commented 2 months ago

In J:346340, Adamtsl2stb homozygootes (Genotype MGI:7628343) are reported to exhibit male infertility due to impotence (first animal model of impotence DOID:1875).

Consider adding impotence under abnormal penile erection MP:0001379 DEF: persistent or recurrent inability to develop or to maintain a penile erection during sexual activity SOURCE: HP:0000802 , https://www.ncbi.nlm.nih.gov/books/NBK562253/ SYN: erectile dysfunction SYN: erectile impotence SYN: male sexual impotence SYN: failure of penile erection SYN: absence of penile erection

Discuss primary term label (impaired penile erection vs impotence vs erectile dysfunction). According to Britannica, because of its pejorative connotation in lay usage and because of confusion about its definition, the word impotence has been eliminated from the technical vocabulary in favour of the term “erectile dysfunction:.

anna-anagnostop commented 2 months ago

Most ontologies including DO, HPO, GSSO (Gender, Sex, and Sexual Orientation ontology) and SNOMED just use impotence in the primary label.

anna-anagnostop commented 2 months ago

Added new term: impotence MP:0031646

CHECK: EQ currently uses: 'has part' some ('decreased process quality' and ('characteristic of' some 'penile erection') and ('has modifier' some abnormal)) -- same as the HPO EQ Used 'decreased process quality' rather than 'absent' to reflect both the inability to develop or to maintain an erection (absent would indicate complete absence of an erection)

Following discussion with Sue, we decided to use 'decreased process quality' in the EQ.