mgijax / mammalian-phenotype-ontology

Standard terms for annotating mammalian phenotypic data
Creative Commons Attribution 4.0 International
19 stars 6 forks source link

abnormal CSF glucose level terms #4009

Open anna-anagnostop opened 4 months ago

anna-anagnostop commented 4 months ago

J:281292 31399478 reports decreased CSF glucose levels in Slc2a1Rgsc200 heterozygotes. For now, I am annotating this to abnormal glucose homeostasis MP:0002078.

See https://en.wikipedia.org/wiki/CSF_glucose for causes of Low CSF glucose levels

Need to create new terms for:

abnormal cerebrospinal fluid glucose level DEF: any deviation from the normal concentration of glucose in the cerebrospinal fluid SYN: abnormal CSF glucose level SOURCE: HP:0031884

decreased cerebrospinal fluid glucose level DEF: less than the normal concentration of glucose in the cerebrospinal fluid SYN: reduced cerebrospinal fluid glucose level SYN: decreased CSF glucose level SYN: reduced CSF glucose level SYN: hypoglycorrhachia SOURCE: HP:0011972, PMID:31399478

increased cerebrospinal fluid glucose level DEF: greater than the normal concentration of glucose in the cerebrospinal fluid SYN: elevated cerebrospinal fluid glucose level SYN: increased CSF glucose level SYN: elevated CSF glucose level SYN: hyperglycorrhachia SOURCE: HP:0031885

Should these be child terms of abnormal cerebrospinal fluid physiology MP:0021024 ? see child terms MP:0021027 and MP:0021082 Currently, there is no term available for abnormal cerebrospinal fluid composition.

anna-anagnostop commented 4 months ago

Added new terms: abnormal cerebrospinal fluid glucose level MP:0031647 decreased cerebrospinal fluid glucose level MP:0031648 increased cerebrospinal fluid glucose level MP:0031649

anna-anagnostop commented 4 months ago

Move abnormal feces composition under digestive system morphology

TO DO: Create new term abnormal cerebrospinal fluid composition under abnormal nervous system morphology.

Should level term in a bodily fluid be under physiology or under morphology branch?

anna-anagnostop commented 4 months ago

Moved abnormal feces composition under digestive system morphology