Activation Induced Cell Death

[obophenotype-user]

Perhaps defects in these pathway need to be listed beneath T and B cell apoptosis. A paper I have now, J:164184 has a mutant in which the B-cells are more susceptible to activation induced cell death. Two reviews that might help. Activation-induced cell death in T cells. PMID: 12752672 and Activation-induced cell death in B lymphocytes. PMID: 11032170. I have spoken with Terry M about GO including this process in its B-cell apoptosis ontology.

Reported by: jbubier

Original Ticket: obo/mammalian-phenotype-requests/779

[obophenotype-user]

-----Original Message----- From: Terry Meehan [mailto:tmeehan@informatics.jax.org] Sent: Thursday, September 30, 2010 2:05 PM To: Jason Bubier Subject: [Fwd: [ geneontology-Ontology requests-3078900 ] activation-induced cell death of B cells]

There is some debate about whether AICD is strictly an apoptotic event but we will keep it under B cell apoptosis for now. Will let you know when its in the GO. Thanks!

-------- Original Message -------- Subject: [ geneontology-Ontology requests-3078900 ] activation-induced cell death of B cells Date: Thu, 30 Sep 2010 18:02:38 +0000 From: SourceForge.net <noreply@sourceforge.net> To: noreply@sourceforge.net

Ontology requests item #3078900, was opened at 2010-09-30 14:02 Message generated for change (Tracker Item Submitted) made by tmeehan6 You can respond by visiting: https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3078900&group\_id=36855

Please note that this message will contain a full copy of the comment thread, including the initial issue submission, for this request, not just the latest update. Category: New term request Group: None Status: Open Resolution: None Priority: 5 Private: No Submitted By: Terry Meehan (tmeehan6) Assigned to: Nobody/Anonymous (nobody) Summary: activation-induced cell death of B cells

Initial Comment: A type of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death. parent term. is_a: GO:0001783 part_of :GO:0001782 : B cell homeostasis synonyms: exact: activation-induced cell death of B lymphocytes exact: activation-induced cell death of B-cells exact: activation-induced cell death of B-lymphocytes broad: activated B cell apoptosis broad: AICD broad: antigen-driven apoptosis see: PMID: 11032170 PMID: 19300454

---

You can respond by visiting: https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3078900&group\_id=36855

Original comment by: jbubier

[obophenotype-user]

Now that GO has added the term, I've added this one to the MP:

abnormal activation-induced B cell apoptosis MP:0010669

see also GO:0071948

also added:

abnormal activation-induced cell death of T cells MP:0010670

Do you think we should have increased/decreased terms as well?

Original comment by: cindyJax

[obophenotype-user]

• assigned_to: nobody --> cynthiasmith
• status: open --> pending-accepted

Original comment by: cindyJax

[obophenotype-user]

I believe the mutant phenotype will often be described as a change, increase or decrease in AICD so those terms would be useful. This article would be increased activation-induced cell death of B cells. I defer to your experience with the Ontology, Is it better to preemptively subdive or retroactively?? Thanks! Jason

Original comment by: jbubier

[obophenotype-user]

• status: pending-accepted --> open-accepted

Original comment by: jbubier

[obophenotype-user]

Preemptive strikes are much better that a retroactive cleanup. In the meantime, I found a few annotations that can be moved to these new terms anyway.

id: MP:0010674 name: increased activation-induced B cell apoptosis

id: MP:0010675 name: decreased activation-induced B cell apoptosis

id: MP:0010676 name: increased activation-induced cell death of T cells

id: MP:0010677 name: decreased activation-induced cell death of T cells

Original comment by: cindyJax

[obophenotype-user]

• status: open-accepted --> closed-accepted

Original comment by: cindyJax