obophenotype-user
commented
13 years ago There are two stages in oogenesis where meiosis is arrested. From the description above, It appears that she is refering to the first stage.
From Wikipedia:
In females, meiosis occurs in cells known as oogonia (singular: oogonium). Each oogonium that initiates meiosis will divide twice to form a single oocyte and two polar bodies.[6] However, before these divisions occur, these cells stop at the diplotene stage of meiosis I and lie dormant within a protective shell of somatic cells called the follicle. Follicles begin growth at a steady pace in a process known as folliculogenesis, and a small number enter the menstrual cycle. Menstruated oocytes continue meiosis I and arrest at meiosis II until fertilization. The process of meiosis in females occurs during oogenesis, and differs from the typical meiosis in that it features a long period of meiotic arrest known as the Dictyate stage and lacks the assistance of centrosomes.
Original comment by: cindyJax
-------- Original Message -------- Subject: FW: MP term: abnormal female meiotic arrest Date: Tue, 9 Nov 2010 17:20:43 -0500 From: Melissa Berry <Melissa.Berry@jax.org> To: Cynthia Smith <csmith@informatics.jax.org>
(yes, I meant child of MP:0005168, abnormal female meiosis, not 5158)
------ Forwarded Message From: Melissa Berry <melissa.berry@jax.org> Date: Tue, 09 Nov 2010 16:57:59 -0500 To: Cynthia Smith <csmith@informatics.jax.org> Conversation: MP term: abnormal female meiotic arrest Subject: MP term: abnormal female meiotic arrest
Child of MP:0005158
J:164870 has abnormal female meiotic arrest which does not exactly qualify as abnormal meiosis (“anomaly in the process of nuclear division that results...”) because it results from the failure of the surrounding granulosa cells or cumulus cells to provide specific proteins that normally cause meiotic arrest in the oocytes. I’ve assigned the phenotype there but it would be better moved down under this requested term. ------ End of Forwarded Message
Reported by: cindyJax
Original Ticket: obo/mammalian-phenotype-requests/825