lung mesenchyme terms

[obophenotype-user]

Please consider adding the following terms as children of “abnormal lung development [MP:0001176]”; some of these terms can be children of abnormal lung interstitium morphology [MP:0002276]; refer to relevant GO terms for consistency

1. abnormal lung-associated mesenchyme development SYN: abnormal lung mesenchyme development SYN: abnormal pulmonary mesenchyme development DEF: failure or abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung

Definition compiled from: 1 An FGF-WNT gene regulatory network controls lung mesenchyme development. Yin Y, White AC, Huh SH, Hilton MJ, Kanazawa H, Long F, Ornitz DM. Dev Biol. 2008 Jul 15;319(2):426-36. Epub 2008 Jun 3. 2 Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. Morimoto M, Liu Z, Cheng HT, Winters N, Bader D, Kopan R.J Cell Sci. 2010 Jan 15;123(Pt 2):213-24. PMID: 20048339

2. thick lung-associated mesenchyme SYN: thickened lung mesenchyme SYN: thick pulmonary mesenchyme SYN: expanded lung mesenchyme DEF: increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development From J:49603, J:91986, J:111447, J:121211, J:75698, J:121155, J:162622, J:163834, J:159690, J:68672, J:159690, J:117072, J:127405,J:29902, J:88090, J:121211, J:121378, J:138576, J:146800, J:158087, J:162622, J:159121, J:142246, J:117072

3. thin lung-associated mesenchyme SYN: thinned lung mesenchyme SYN: thin pulmonary mesenchyme SYN: reduced lung mesenchyme DEF: decreased thickness of the mesenchymal cell layer in the developing lung From J:132655, J:104565

4. abnormal mesenchymal cell differentiation involved in lung development SYN: abnormal lung mesenchymal cell differentiation SYN: abnormal pulmonary mesenchymal cell differentiation DEF: abnormal or arrest of differentiation of the mesenchymal cell population in the developing lung From J:85424, J:90274, J:121211, J:153098, J:158087

5. abnormal mesenchymal cell proliferation involved in lung development SYN: abnormal lung mesenchymal cell proliferation SYN: abnormal pulmonary mesenchymal cell proliferation DEF: anomaly in the ability of the differentiating lung mesenchymal cell population to undergo expansion by cell division in the developing lung From J:79395

5a. increased mesenchymal cell proliferation involved in lung development SYN: increased lung mesenchymal cell proliferation SYN: increased pulmonary mesenchymal cell proliferation DEF: increase in the expansion rate of a lung mesenchymal cell population by cell division From J:53721, J:146617, J:166788

5b. decreased mesenchymal cell proliferation involved in lung development SYN: decreased lung mesenchymal cell proliferation SYN: decreased pulmonary mesenchymal cell proliferation DEF: decrease in the expansion rate of a lung mesenchymal cell population by cell division From J:130165, J:124125, J:49603, J:69852, J:100263, J:134483, J:121421

Thanks

Anna

Reported by: anna_anagnos

Original Ticket: obo/mammalian-phenotype-requests/943

[obophenotype-user]

New terms added:

id: MP:0011142 name: abnormal lung-associated mesenchyme development

id: MP:0011143 name: thick lung-associated mesenchyme

id: MP:0011144 name: thin lung-associated mesenchyme

id: MP:0011145 name: abnormal mesenchymal cell differentiation involved in lung development

id: MP:0011146 name: abnormal mesenchymal cell proliferation involved in lung development

id: MP:0011147 name: increased mesenchymal cell proliferation involved in lung development

id: MP:0011148 name: decreased mesenchymal cell proliferation involved in lung development

Original comment by: cindyJax

[obophenotype-user]

• assigned_to: nobody --> cynthiasmith
• status: open --> closed-accepted

Original comment by: cindyJax