only 3 genes (sven_4179, sven_4180 and sven_4181) direct the production of gaburedin natural products, the additional genes currently shown as part of the gaburedin cluster are involved in the production of furan (analogous to butyrolactones) signalling molecules and should be omitted. The function of the 3 genes (sven_4179, sven_4180 and sven_4181) has been investigated, they are: sven_4179 = glutamate decarboxylase, sven_4180 = urea synthetase and sven_4181 = gaburedin exporter. Having the additional genes (sven_4182-sven4188) result in BGC regulated by furans coming up as being predicted as potentially directing the production of gaburedins while they are completely directing the production of completely distinct structural classes of natural products such as methylenomycins or scleric acid)
BGC0002578
only 3 genes (sven_4179, sven_4180 and sven_4181) direct the production of gaburedin natural products, the additional genes currently shown as part of the gaburedin cluster are involved in the production of furan (analogous to butyrolactones) signalling molecules and should be omitted. The function of the 3 genes (sven_4179, sven_4180 and sven_4181) has been investigated, they are: sven_4179 = glutamate decarboxylase, sven_4180 = urea synthetase and sven_4181 = gaburedin exporter. Having the additional genes (sven_4182-sven4188) result in BGC regulated by furans coming up as being predicted as potentially directing the production of gaburedins while they are completely directing the production of completely distinct structural classes of natural products such as methylenomycins or scleric acid)
10.1039/c3sc52536h