I wanted to suggest updating the information on mic cluster to include the compound dehydromicroperfuranone which is the product of micA(ANIA_03396) and micB (ANIA_03394 ) SMILES: O=C1C(CC2=CC=CC=C2)=C(C3=CC=CC=C3)C(O1)=O .
Also updating on ANIA_03394 : Function: cytochrome P450 monooxygenase Evidence: Gene overexpression
To support this, also adding in the literature Roux et al 2020 (reference below).
I also would suggest referring to "EQ-4" as microperfuranone, as this is the name of the compound used in Yeh et al 2012 and the rest of Aspergillus literature. Thanks!
CRISPR-Mediated Activation of Biosynthetic Gene Clusters for Bioactive Molecule Discovery in Filamentous Fungi
Indra Roux, Clara Woodcraft, Jinyu Hu, Rebecca Wolters, Cameron L. M. Gilchrist, and Yit-Heng Chooi
ACS Synthetic Biology 2020 9 (7), 1843-1854
DOI: 10.1021/acssynbio.0c00197
kblin
commented
3 years ago
BGC0001668
I wanted to suggest updating the information on mic cluster to include the compound dehydromicroperfuranone which is the product of micA(ANIA_03396) and micB (ANIA_03394 ) SMILES: O=C1C(CC2=CC=CC=C2)=C(C3=CC=CC=C3)C(O1)=O . Also updating on ANIA_03394 : Function: cytochrome P450 monooxygenase Evidence: Gene overexpression To support this, also adding in the literature Roux et al 2020 (reference below). I also would suggest referring to "EQ-4" as microperfuranone, as this is the name of the compound used in Yeh et al 2012 and the rest of Aspergillus literature. Thanks!
CRISPR-Mediated Activation of Biosynthetic Gene Clusters for Bioactive Molecule Discovery in Filamentous Fungi Indra Roux, Clara Woodcraft, Jinyu Hu, Rebecca Wolters, Cameron L. M. Gilchrist, and Yit-Heng Chooi ACS Synthetic Biology 2020 9 (7), 1843-1854 DOI: 10.1021/acssynbio.0c00197