Cryptococcus NTR: non-lytic exocytosis (from host cell)

[dianeoinglis]

Cryptococcus cells can escape macrophages while leaving the macrophages intact. The term used is non-lytic exocytosis. There is an unfortunate synonym in use for Cryptococcus that perhaps should be referenced as a synonym : "vomitocytosis"

• "non-lytic exocytosis of microbe phenotype" or "non-lytic exocytosis phenotype"
• "altered non-lytic exocytosis of microbe phenotype" -"non-lytic exocytosis of microbe phenotype" (with the qualifiers ncreased, decreased and abolished)

I think including the term "microbe" makes it clear that the cargo is the microbe.

Here are a few references. Global analysis of fungal morphology exposes mechanisms of host cell escape. PMID: 25824284

Temporal kinetics and quantitative analysis of Cryptococcus neoformans nonlytic exocytosis. PMID: 24595144

Thank you! Diane

[dianeoinglis]

I came across articles that use "expulsion" or "extrusion" to refer to non-lytic exocytosis as a means for Cryptococcus and Candida to escape from host phagocytes and/or amoebe. I am not sure the evidence for exocytosis is definitive. "expulsion"may be a better term for this process. I have a revised NTR:

altered/increased/decreased/abolished..."non-lytic expulsion from host cell (or phagocyte) phenotype"

Thank you, Diane