Open ssarrafan opened 10 months ago
Rescheduled for Q4 of this year per the milestones spreadsheet.
Also renamed: (MODIFIED) Modify reference metagenome-independent metaproteomics workflow; retrain the peptide-spectrum ML model, and redesign protein sequence database generation
per checkin meeting @picowatt thinks we are on track for this quarter. cc @SamuelPurvine
Expanding the metaproteomics workflow There are two limitations of the current metaproteomics workflow that limit its utility for the community, (i) peptide sequence identification currently requires a matched metagenome for streamlined query, and (ii) all data sets are treated independently which precludes sample comparisons by relative quantitation. To provide an alternative workflow that removes the requirement for a metagenome, the metaproteomics workflow will use an EMSL developed tool75 that uses a machine learning model to identify peptide sequences de novo, and then uses these sequences to predict taxonomy and derive a pseudo-metagenome for use as the input database (Milestone 2.14).
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