Integration of multiomics data

[mohamadysn]

Hello,

I work with three types of omics data (transcriptomics (RNA-seq or scRNA-seq), methylome (EM-seq) and epigenomics (Chip-seq) in Alzheimer’s disease. Can I use Mixomics to integrate these three types together? If so, how? and what should I do with this data before using mixOmics?

Thank you in advance

[Max-Bladen]

Hi @mohamadysn

Unfortunately, your question is very bare-bones, making it difficult to answer properly. The short answer is yes, you can use mixOmics. By the sounds of it, you have a categorical response variable (presence of Alzheimer's), so you would want to look up the DIABLO method. I can't tell you exactly what you need to do as you haven't provided any context.

Also, I'd recommend looking at the website. I've filled it with tons of info on Selecting a method. There are also pages corresponding to basic usage and specific case studies for the DIABLO method (assuming that this is appropriate for your use).