Optimize ranking

[Char-Al]

Ranking : from 1 to 10 and score

• [x] 1. clinvar_pathogenicity : Pathogenic variants reported on ClinVar (score : 10)
• [x] 2. stop or frameshift_impact : Premature Truncation Codon : nonsense or frameshift (score : 10)
• [x] 3. splicing_impact (ADA, RF) : Affecting splice variants predictions ranked by algorithm performance robustness and strength (score : 10)
• [x] 4. splicing_impact (spliceAI high) : Affecting splice variants predictions ranked by algorithm performance robustness and strength (score : 10)
• [x] 5. missense impact moderate to high impact (6-10)
• [x] 6. moderate splicing_impact (spliceAI moderate) (score 6)
• [x] 7. missense_impact moderate : Missense variants scores low impact (score : 2-6)
• [x] 8. low splicing impact (spliceAI low) (indel) (score : 2)
• [x] 9. missense_impact low : Missense variants scores low impact (score : 0-2)
• [x] 10. unknown impact : Exonic variants with not clearly annotated ORFs and splicing variants not predicted pathogenic ; or NULL (no annotation on genes, splice etc...) (score : 0-10)