Currently gene symbols with invalid casing (e.g. all lower-case) are considered as valid gene symbols. This results in an issue when determining consensus due to different gene-variant identifiers. Furthermore downstream users (e.g. VEP VKGL plugin or Alissa) have to take into account these casing issues when coupling data.
Gene-variants with gene symbols with invalid casing should be written to the error file with a message stating that the gene symbol is invalid because it contains lower-case characters.
source: https://www.genenames.org/about/guidelines/
Currently gene symbols with invalid casing (e.g. all lower-case) are considered as valid gene symbols. This results in an issue when determining consensus due to different gene-variant identifiers. Furthermore downstream users (e.g. VEP VKGL plugin or Alissa) have to take into account these casing issues when coupling data.
Gene-variants with gene symbols with invalid casing should be written to the error file with a message stating that the gene symbol is invalid because it contains lower-case characters.