Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy #129

Closed pnrobinson closed 4 years ago

pnrobinson commented 4 years ago

https://pubmed.ncbi.nlm.nih.gov/29232553/

pnrobinson commented 4 years ago

concomitant p53 activation and Bcl-2 inhibition overcome apoptosis resistance and markedly prolong survival in three mouse models of resistant acute myeloid leukemia (AML). Combining the p53 activator RG with ABT at a 5:1 or 1:1 ratio augmented apoptosis and reduced live cell numbers to a significantly greater extent than either agent alone

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