DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1

pnrobinson commented 4 years ago

pnrobinson commented 4 years ago

Germline mutations in the MMR genes MLH1 or MSH2 predispose to hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome, which accounts for approximately 5% of all colorectal cancer cases
Reactive oxygen species, generated by sources such as the normal metabolic processes of cells as well as environmental agents, are genotoxic, producing DNA base lesions such as 8-oxoguanine (8-oxoG)
To assess SSL interactions in human cells, we used isogenic models of MLH1 or MSH2 deficiency.

pnrobinson commented 4 years ago

done

monarch-initiative / SLDBGen