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monarch-initiative / SLDBGen

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Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data #148

Closed pnrobinson closed 4 years ago

pnrobinson commented 4 years ago

https://pubmed.ncbi.nlm.nih.gov/28561042/

We extensively validate a SL interaction identified by MiSL between the IDH1 mutation and ACACA in leukaemia using gene targeting and patient-derived xenografts.

pnrobinson commented 4 years ago

done