Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

monarch-initiative / SLDBGen

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR #151

Closed pnrobinson closed 4 years ago

pnrobinson commented 4 years ago

https://pubmed.ncbi.nlm.nih.gov/22281684/

pnrobinson commented 4 years ago

To identify genes that are synthetic lethal to IDF-11774, we carried out RNAi screening using pooled lentiviruses expressing an shRNA library and then isolated the genes whose knockdown induced a synergistic growth-inhibitory effect in cancer cells in the presence of IDF-11774.

pnrobinson commented 4 years ago

done