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monarch-initiative / SLDBGen

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Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer #169

Closed pnrobinson closed 3 years ago

pnrobinson commented 4 years ago

https://pubmed.ncbi.nlm.nih.gov/30030148/

pnrobinson commented 3 years ago

search for kinases whose knockout synergizes with sorafenib since sorafenib is a multikinase inhibitor, we cannot curate specific gene-gene SLIs