We are often asked to generate gene sets based on filters, that amount to generating gene sets and performing set operations on them. We could theoretically introduce this functionality to biolink, by caching sets and then passing operations as a REST param, as an example:
We generate and cache the following sets:
A. All human protein coding genes
B. Human protein coding genes with mouse ortholog
C. Genes with ortholog-phenotypes in any species
D. Genes with phenotypes in human
E. Genes with ortholog-phenotypes in mouse
An example query:
Get the list of genes that have a mouse ortholog and no phenotypes in human OR mouse but have a phenotype in some other species
We are often asked to generate gene sets based on filters, that amount to generating gene sets and performing set operations on them. We could theoretically introduce this functionality to biolink, by caching sets and then passing operations as a REST param, as an example:
We generate and cache the following sets: A. All human protein coding genes B. Human protein coding genes with mouse ortholog C. Genes with ortholog-phenotypes in any species D. Genes with phenotypes in human E. Genes with ortholog-phenotypes in mouse
An example query: Get the list of genes that have a mouse ortholog and no phenotypes in human OR mouse but have a phenotype in some other species
Would be: A & B & C - D - E