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monarch-initiative / genophenocorr

Genotype Phenotype Correlation
https://monarch-initiative.github.io/genophenocorr/stable
MIT License
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More mtc heuristic #178

Closed pnrobinson closed 7 hours ago

pnrobinson commented 2 days ago

I could use a hand in setting up a unit test -- can we make a small cohort with two HPO terms and missense vis nonsense?

ielis commented 1 day ago

Maybe we could use a Phenopacket store cohort? Would you have a candidate there?

pnrobinson commented 16 hours ago

This PR adds the ability to set a minimum frequency to have in at least one genotype for the HeuristicMtcFilter See test_min_observed_HPO_threshold in test_mtc_filter for the key part of the function.