NCIT_C42065 Mature Ganglioneuroma

[nicolevasilevsky]

NCIT_C42065	Mature Ganglioneuroma	SubClassOf	DOID_4817	ganglioneuroma

[nicolevasilevsky]

I think this is okay, as NCIT already asserts this relationship.

[cmungall]

I agree!

However, before we close this we should investigate why the global probability of this was low enough to be flagged: It's the connection to gangliocytomas, note the low probabilities of the individual linkages.

Do you think there should be a connection between ganglioneuroma and gangliocytoma?

[cmungall]

here is how different ontologies classify this (no inter-ontology linkages shown):

• NCIT:C3049 ! Ganglioneuroma [DEF: "A benign neuroblastic tumor of the sympathetic nervous system that occurs in childhood. Ganglioneuroma typically arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. Common presenting features include a palpable abdominal mass, hepatomegaly, and a thoracic mass detected on routine chest X-ray."]
• NCIT:C6934 ! Gangliocytoma [DEF: "A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, mature ganglion cells."]

TL;DR - we dispute the DO xrefs, and we should assert these to be sibs

[nicolevasilevsky]

This is related to #317