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monarch-initiative / monarch-legacy

Monarch web application and API
BSD 3-Clause "New" or "Revised" License
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Consider a druggable genome view #1290

Open mellybelly opened 8 years ago

mellybelly commented 8 years ago

We have a lot of model data relevant to the Illuminating the druggable genome project. See: The human genome and drug discovery after a decade. Roads (still) not taken http://arxiv.org/abs/1102.0448 and the program website: http://www.ncats.nih.gov/idg

We had a preliminary analysis of these genes, attached. image Drug and phenotype annotation coverage in Monarch for genes in each of the four druggable gene families. Only ~25% of genes have known drug targets (+drug), nearly all of which also have phenotype annotations in human (H) or model (M) organisms. Phenotypes alone add value for comparative analysis, approaching up to 90% coverage for these gene families. Human phenotypes are from OMIM and GWAS; models span mouse, rat, fish, fly, and worm orthologs. (n=#genes per class.)

@cmungall

jmcmurry commented 8 years ago

Where is the data about which genes are members of these families?

mellybelly commented 8 years ago

@nlwashington can you remind us how you generated these gene lists?