sagehrke
commented
3 weeks ago Dear @galyea123, Thank you for reaching out to the Mondo Disease Ontology, part of the Monarch Initiative!
We have received your ticket and will review it as soon as possible.
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Sincerely, The Mondo Team
galyea123
Label
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD)
Synonyms
MOGAD
Synonym type
exact
Definition
Request to add a new disease:
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an inflammatory demyelinating disease of the central nervous system (CNS) with the presence of conformation-sensitive antibodies against MOG. The spectrum of MOGAD includes monophasic/relapsing optic neuritis, myelitis, neuromyelitis optica spectrum disorder (NMOSD) phenotype without aquaporin 4 (AQP4) antibodies, acute/multiphasic demyelinating encephalomyelitis (ADEM/MDEM)-like presentation, and brainstem and cerebral cortical encephalitis. The prevalence of MOGAD is approximately 1.3–2.5/100,000. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542411/
NOTE: I noticed that MONDO list the following that are included in MOGAD:
From the same source: "The MOG antibodies were initially detected primarily in a subgroup of patients with acute/multiphasic demyelinating encephalomyelitis (ADEM/MDEM) (2, 3). Subsequent studies showed that MOG antibodies were also present in patients with optic neuritis, myelitis, neuromyelitis optica spectrum disorder (NMOSD) phenotype without aquaporin 4 (AQP4) antibodies, and brainstem and cerebral cortical encephalitis; Recently, the international diagnostic criteria for MOGAD were published (12), and the diagnosis of MOGAD is now made based on the presence of at least one of the core clinical demyelinating events (optic neuritis, myelitis, ADEM, cerebral monofocal or polyfocal deficits, brainstem or cerebellar deficits, and cerebral cortical encephalitis often with seizures), a positive MOG-IgG test, and the exclusion of alternative diagnoses including MS."
See also: MOGAD is now recognized as an autonomous, antibody-mediated inflammatory demyelinating disorder, most frequently with relapsing course and a variety of clinical manifestations. As it is a rare condition, researchers should still focus on the different aspects of the disease: its pathophysiological mechanisms, the identification of markers of the disease status and outcome, the incidence in various regions and patients populations. All of the above should form the basis for development and elaboration of the MOGAD diagnosis criteria to be ultimately approved by experts. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795410/
We have a NORD report.
Thank you, Gioconda Alyea
Parent term
inflammatory demyelinating disease of the central nervous system
Children term(s)
No response
ORCID Identifier
0000-001-9310-0163
Website URL
No response
Additional comments
No response